| Title: |
The end of the reign of a 'master regulator’’? A defect in function of the LasR quorum sensing regulator is a common feature of Pseudomonas aeruginosa isolates |
| Authors: |
Mylène C. Trottier, Thays de Oliveira Pereira, Marie-Christine Groleau, Lucas R. Hoffman, Ajai A. Dandekar, Eric Déziel |
| Source: |
mBio, Vol 15, Iss 3 (2024) |
| Publisher Information: |
American Society for Microbiology, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
quorum sensing, Pseudomonas aeruginosa, virulence regulation, ecology, adaptive mutations, opportunistic infections, Microbiology, QR1-502 |
| More Details: |
ABSTRACT Pseudomonas aeruginosa, a bacterium causing infections in immunocompromised individuals, regulates several of its virulence functions using three interlinked quorum sensing (QS) systems (las, rhl, and pqs). Despite its presumed importance in regulating virulence, dysfunction of the las system regulator LasR occurs frequently in strains isolated from various environments, including clinical infections. This newfound abundance of LasR-defective strains calls into question existing hypotheses regarding their selection. Indeed, current assumptions concerning factors driving the emergence of LasR-deficient isolates and the role of LasR in the QS hierarchy must be reconsidered. Here, we propose that LasR is not the primary master regulator of QS in all P. aeruginosa genetic backgrounds, even though it remains ecologically significant. We also revisit and complement current knowledge on the ecology of LasR-dependent QS in P. aeruginosa, discuss the hypotheses explaining the putative adaptive benefits of selecting against LasR function, and consider the implications of this renewed understanding. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2150-7511 |
| Relation: |
https://doaj.org/toc/2150-7511 |
| DOI: |
10.1128/mbio.02376-23 |
| Access URL: |
https://doaj.org/article/6edfb6c216cc4837b0609d1cfccc41f6 |
| Accession Number: |
edsdoj.6edfb6c216cc4837b0609d1cfccc41f6 |
| Database: |
Directory of Open Access Journals |
