Acute kidney injury in Japanese type 2 diabetes patients receiving sodium–glucose cotransporter 2 inhibitors: A nationwide cohort study
| Title: | Acute kidney injury in Japanese type 2 diabetes patients receiving sodium–glucose cotransporter 2 inhibitors: A nationwide cohort study |
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| Authors: | Takeshi Horii, Yoichi Oikawa, Narumi Kunisada, Akira Shimada, Koichiro Atsuda |
| Source: | Journal of Diabetes Investigation, Vol 13, Iss 1, Pp 42-46 (2022) |
| Publisher Information: | Wiley, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | Acute kidney injury, Risk factors, Sodium–glucose cotransporter 2 inhibitors, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Abstract The present retrospective study aimed to identify factors associated with an increased risk of acute kidney injury in Japanese patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors. We identified 171,622 patients with type 2 diabetes treated with sodium–glucose cotransporter 2 inhibitors; among them, 476 (0.3%) patients developed acute kidney injury. The hazard ratio for acute kidney injury occurrence risk was analyzed using a Cox proportional hazards model adjusted for patient characteristics at baseline and use of concomitant agents. In the adjusted model, patients who developed acute kidney injury were mostly men, aged ≥65 years, had lower body mass index, had a history of heart failure and used diuretics more frequently than those who did not. These findings suggest that associated clinical risk factors should be thoroughly evaluated before administering sodium–glucose cotransporter 2 inhibitors to minimize acute kidney injury onset. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2040-1124 2040-1116 |
| Relation: | https://doaj.org/toc/2040-1116; https://doaj.org/toc/2040-1124 |
| DOI: | 10.1111/jdi.13630 |
| Access URL: | https://doaj.org/article/6eaa410ddd74415d82c64b66941d0b49 |
| Accession Number: | edsdoj.6eaa410ddd74415d82c64b66941d0b49 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20401124 20401116 |
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| DOI: | 10.1111/jdi.13630 |
| Published in: | Journal of Diabetes Investigation |
| Language: | English |