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Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants

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Title: Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants
Authors: Alice Koenig, Chien-Chia Chen, Antoine Marçais, Thomas Barba, Virginie Mathias, Antoine Sicard, Maud Rabeyrin, Maud Racapé, Jean-Paul Duong-Van-Huyen, Patrick Bruneval, Alexandre Loupy, Sébastien Dussurgey, Stéphanie Ducreux, Vannary Meas-Yedid, Jean-Christophe Olivo-Marin, Héléna Paidassi, Romain Guillemain, Jean-Luc Taupin, Jasper Callemeyn, Emmanuel Morelon, Antonino Nicoletti, Béatrice Charreau, Valérie Dubois, Maarten Naesens, Thierry Walzer, Thierry Defrance, Olivier Thaunat
Source: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Publisher Information: Nature Portfolio, 2019.
Publication Year: 2019
Collection: LCC:Science
Subject Terms: Science
More Details: ‘Missing self’ is a mode of natural killer (NK) cell activation aimed to detect the lack of HLA-I molecules on infected or neoplastic cells. Here, the authors show that mismatch between donor HLA-I and cognate receptors on recipient NK cells mediates microvascular inflammation-associated graft rejection, a pathology that is preventable by mTOR inhibition.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-019-13113-5
Access URL: https://doaj.org/article/6e54e790902d416d9bb11f07312515cd
Accession Number: edsdoj.6e54e790902d416d9bb11f07312515cd
Database: Directory of Open Access Journals
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