Bibliographic Details
| Title: |
Alterations in Th17 Cells and Non-Classical Monocytes as a Signature of Subclinical Coronary Artery Atherosclerosis during ART-Treated HIV-1 Infection |
| Authors: |
Tomas Raul Wiche Salinas, Yuwei Zhang, Annie Gosselin, Natalia Fonseca Rosario, Mohamed El-Far, Ali Filali-Mouhim, Jean-Pierre Routy, Carl Chartrand-Lefebvre, Alan L. Landay, Madeleine Durand, Cécile L. Tremblay, Petronela Ancuta |
| Source: |
Cells, Vol 13, Iss 2, p 157 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Cytology |
| Subject Terms: |
HIV-1, antiretroviral therapy (ART), cardiovascular disease (CVD), Th17/Treg cells, non-classical monocytes, myeloid/plasmacytoid dendritic cells, Cytology, QH573-671 |
| More Details: |
Cardiovascular disease (CVD) remains an important comorbidity in people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Our previous studies performed in the Canadian HIV/Aging Cohort Study (CHACS) (>40 years-old; Framingham Risk Score (FRS) > 5%) revealed a 2–3-fold increase in non-calcified coronary artery atherosclerosis (CAA) plaque burden, measured by computed tomography angiography scan (CTAScan) as the total (TPV) and low attenuated plaque volume (LAPV), in ART-treated PLWH (HIV+) versus uninfected controls (HIV−). In an effort to identify novel correlates of subclinical CAA, markers of intestinal damage (sCD14, LBP, FABP2); cell trafficking/inflammation (CCL20, CX3CL1, MIF, CCL25); subsets of Th17-polarized and regulatory (Tregs) CD4+ T-cells, classical/intermediate/non-classical monocytes, and myeloid/plasmacytoid dendritic cells were studied in relationship with HIV and TPV/LAPV status. The TPV detection/values coincided with higher plasma sCD14, FABP2, CCL20, MIF, CX3CL1, and triglyceride levels; lower Th17/Treg ratios; and classical monocyte expansion. Among HIV+, TPV+ versus TPV− exhibited lower Th17 frequencies, reduced Th17/Treg ratios, higher frequencies of non-classical CCR9lowHLADRhigh monocytes, and increased plasma fibrinogen levels. Finally, Th17/Treg ratios and non-classical CCR9lowHLADRhigh monocyte frequencies remained associated with TPV/LAPV after adjusting for FRS and HIV/ART duration in a logistic regression model. These findings point to Th17 paucity and non-classical monocyte abundance as novel immunological correlates of subclinical CAA that may fuel the CVD risk in ART-treated PLWH. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2073-4409 |
| Relation: |
https://www.mdpi.com/2073-4409/13/2/157; https://doaj.org/toc/2073-4409 |
| DOI: |
10.3390/cells13020157 |
| Access URL: |
https://doaj.org/article/6e3d5b0e9ac945fea97b1abf8a1ce930 |
| Accession Number: |
edsdoj.6e3d5b0e9ac945fea97b1abf8a1ce930 |
| Database: |
Directory of Open Access Journals |
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