Bestatin attenuates breast cancer stemness by targeting puromycin-sensitive aminopeptidase

Bibliographic Details
Title: Bestatin attenuates breast cancer stemness by targeting puromycin-sensitive aminopeptidase
Authors: Yan Ma, Xintong Yang, Pengge Pan, Jinyi Yang, Xiaojuan Wu, Danhan Wang, Hui Gao
Source: Discover Oncology, Vol 15, Iss 1, Pp 1-10 (2024)
Publisher Information: Springer, 2024.
Publication Year: 2024
Collection: LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Subject Terms: Breast cancer, Bestatin, Breast cancer stem cells, Puromycin-sensitive aminopeptidase, Apoptosis, Proliferation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
More Details: Abstract Breast cancer is a prevalent malignant tumor among women with an increasing incidence rate annually. Breast cancer stem cells (BCSCs) are integral in impeding tumor advancement and addressing drug resistance. Bestatin serves as an adjuvant chemotherapy, triggering apoptosis in cancer cells. In this study, the effects of bestatin on sorted BCSCs from breast cancer cell lines have been studied. Our results indicated that bestatin inhibits the migration and proliferation of breast cancer cells by reducing the stemness of BCSCs both in vitro and in vivo. Puromycin-sensitive aminopeptidase is implicated in the process through the regulation of cell cycle, resulting in heightened cell apoptosis and diminished cell proliferation of BCSCs. Our study suggest that targeting cancer stem cell may offer a promising approach in breast cancer treatment, presenting noval therapeutic strategies for patients with breast cancer.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2730-6011
Relation: https://doaj.org/toc/2730-6011
DOI: 10.1007/s12672-024-01063-4
Access URL: https://doaj.org/article/e6e2494c7a584c54a49316c4b8dae155
Accession Number: edsdoj.6e2494c7a584c54a49316c4b8dae155
Database: Directory of Open Access Journals
More Details
ISSN:27306011
DOI:10.1007/s12672-024-01063-4
Published in:Discover Oncology
Language:English