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Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses

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Title: Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses
Authors: Peipei Wu, Jihu Lu, Xuehua Zhang, Mei Mei, Lei Feng, Daxin Peng, Jibo Hou, Sang-Moo Kang, Xiufan Liu, Yinghua Tang
Source: Frontiers in Immunology, Vol 8 (2017)
Publisher Information: Frontiers Media S.A., 2017.
Publication Year: 2017
Collection: LCC:Immunologic diseases. Allergy
Subject Terms: H5 subtype influenza virus, vaccine, consensus, virus-like particles, broad protection, Immunologic diseases. Allergy, RC581-607
More Details: The H5 subtype highly pathogenic avian influenza (HPAI) virus is one of the greatest threats to global poultry industry. To develop broadly protective H5 subunit vaccine, a recombinant consensus HA sequence (rHA) was constructed and expressed in virus-like particles (rHA VLPs) in the baculovirus-insect cell system. The efficacy of the rHA VLPs vaccine with or without immunopotentiator (CVCVA5) was assessed in chickens. Compared to the commercial Re6 or Re6-CVCVA5 vaccines, single dose immunization of chickens with rHA VLPs or rHA-CVCVA5 vaccines induced higher levels of serum hemagglutinin inhibition titers and neutralization titers, mucosal antibodies, IFN-γ and IL-4 cytokines in sera, and cytotoxic T lymphocyte responses. The rHA VLPs vaccine was superior to the commercial Re6 vaccine in conferring cross-protection against different clades of H5 subtype viruses. This study reports that H5 subtype consensus HA VLP single dose vaccination provides broad protection against HPAI virus in chickens.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1664-3224
Relation: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01649/full; https://doaj.org/toc/1664-3224
DOI: 10.3389/fimmu.2017.01649
Access URL: https://doaj.org/article/6d7234584ce441cd8d286c207a175903
Accession Number: edsdoj.6d7234584ce441cd8d286c207a175903
Database: Directory of Open Access Journals
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  Data: Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses
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  Data: <searchLink fieldCode="AR" term="%22Peipei+Wu%22">Peipei Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Jihu+Lu%22">Jihu Lu</searchLink><br /><searchLink fieldCode="AR" term="%22Xuehua+Zhang%22">Xuehua Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Mei+Mei%22">Mei Mei</searchLink><br /><searchLink fieldCode="AR" term="%22Lei+Feng%22">Lei Feng</searchLink><br /><searchLink fieldCode="AR" term="%22Daxin+Peng%22">Daxin Peng</searchLink><br /><searchLink fieldCode="AR" term="%22Jibo+Hou%22">Jibo Hou</searchLink><br /><searchLink fieldCode="AR" term="%22Sang-Moo+Kang%22">Sang-Moo Kang</searchLink><br /><searchLink fieldCode="AR" term="%22Xiufan+Liu%22">Xiufan Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Yinghua+Tang%22">Yinghua Tang</searchLink>
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  Data: Frontiers in Immunology, Vol 8 (2017)
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  Data: LCC:Immunologic diseases. Allergy
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  Data: <searchLink fieldCode="DE" term="%22H5+subtype+influenza+virus%22">H5 subtype influenza virus</searchLink><br /><searchLink fieldCode="DE" term="%22vaccine%22">vaccine</searchLink><br /><searchLink fieldCode="DE" term="%22consensus%22">consensus</searchLink><br /><searchLink fieldCode="DE" term="%22virus-like+particles%22">virus-like particles</searchLink><br /><searchLink fieldCode="DE" term="%22broad+protection%22">broad protection</searchLink><br /><searchLink fieldCode="DE" term="%22Immunologic+diseases%2E+Allergy%22">Immunologic diseases. Allergy</searchLink><br /><searchLink fieldCode="DE" term="%22RC581-607%22">RC581-607</searchLink>
– Name: Abstract
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  Data: The H5 subtype highly pathogenic avian influenza (HPAI) virus is one of the greatest threats to global poultry industry. To develop broadly protective H5 subunit vaccine, a recombinant consensus HA sequence (rHA) was constructed and expressed in virus-like particles (rHA VLPs) in the baculovirus-insect cell system. The efficacy of the rHA VLPs vaccine with or without immunopotentiator (CVCVA5) was assessed in chickens. Compared to the commercial Re6 or Re6-CVCVA5 vaccines, single dose immunization of chickens with rHA VLPs or rHA-CVCVA5 vaccines induced higher levels of serum hemagglutinin inhibition titers and neutralization titers, mucosal antibodies, IFN-γ and IL-4 cytokines in sera, and cytotoxic T lymphocyte responses. The rHA VLPs vaccine was superior to the commercial Re6 vaccine in conferring cross-protection against different clades of H5 subtype viruses. This study reports that H5 subtype consensus HA VLP single dose vaccination provides broad protection against HPAI virus in chickens.
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  Data: http://journal.frontiersin.org/article/10.3389/fimmu.2017.01649/full; https://doaj.org/toc/1664-3224
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      – Text: English
    Subjects:
      – SubjectFull: H5 subtype influenza virus
        Type: general
      – SubjectFull: vaccine
        Type: general
      – SubjectFull: consensus
        Type: general
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      – SubjectFull: Immunologic diseases. Allergy
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      – SubjectFull: RC581-607
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      – TitleFull: Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses
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