Academic Journal
Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan
| Title: | Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan |
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| Authors: | Miae Oh, Jiah Yeom, Ulrich Schraermeyer, Sylvie Julien-Schraermeyer, Young-Hee Lim |
| Source: | Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022) |
| Publisher Information: | Nature Portfolio, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Lipofuscin is a representative biomarker of aging that is generated naturally over time. Remofuscin (soraprazan) improves age-related eye diseases by removing lipofuscin from retinal pigment epithelium (RPE) cells. In this study, the effect of remofuscin on longevity in Caenorhabditis elegans and the underlying mechanism were investigated. The results showed that remofuscin significantly (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-022-11325-2 |
| Access URL: | https://doaj.org/article/6d68113d8a2e4de2aaba55d7f00d9217 |
| Accession Number: | edsdoj.6d68113d8a2e4de2aaba55d7f00d9217 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-022-11325-2 |
| Published in: | Scientific Reports |
| Language: | English |