Bibliographic Details
| Title: |
Persistent complete molecular remission after nilotinib and graft-versus-leukemia effect in an acute lymphoblastic leukemia patient with cytogenetic relapse after allogeneic stem cell transplantation |
| Authors: |
Farnsworth Paul, Ward David, Reddy Vijay |
| Source: |
Experimental Hematology & Oncology, Vol 1, Iss 1, p 29 (2012) |
| Publisher Information: |
BMC, 2012. |
| Publication Year: |
2012 |
| Collection: |
LCC:Diseases of the blood and blood-forming organs
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Philadelphia chromosome positive acute lymphoblastic leukemia (PH + ALL), Nilotinib, Extracorporeal photopheresis (ECP), Graft-versus-host disease (GVHD), Graft-versus-leukemia effect (GVL), Hematopoietic stem cell transplantation (HSCT), Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Abstract We report the successful treatment and sustained molecular remission using single agent nilotinib in a relapsed Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia patient after allogeneic hematopoietic stem cell transplantation. Compared to previously published studies, this is the first report where a patient did not receive additional chemotherapy after relapse, nor did she receive donor lymphocyte infusions. With nilotinib, the patient reverted back to normal blood counts and 100% donor reconstitution by single tandem repeat (STR) chimerism analysis in the bone marrow and in peripheral blood, granulocytes, T and B-lymphocytes. This report also highlights the use of nilotinib in combination with extracorporeal photopheresis (ECP) for concomitant graft-versus-host disease. Our data suggests that ECP, together with nilotinib, did not adversely affect the overall Graft-versus-leukemia (GVL) effect. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2162-3619 |
| Relation: |
http://www.ehoonline.org/content/1/1/29; https://doaj.org/toc/2162-3619 |
| DOI: |
10.1186/2162-3619-1-29 |
| Access URL: |
https://doaj.org/article/6d319e38146d404eae5a3e8b6329f71e |
| Accession Number: |
edsdoj.6d319e38146d404eae5a3e8b6329f71e |
| Database: |
Directory of Open Access Journals |
