Bibliographic Details
| Title: |
An increase in erythromycin resistance in methicillin-susceptible Staphylococcus aureus from blood correlates with the use of macrolide/lincosamide/streptogramin antibiotics. EARS-Net Spain (2004–2020) |
| Authors: |
Achraf El Mammery, Eva Ramírez de Arellano, Javier E. Cañada-García, Emilia Cercenado, Laura Villar-Gómara, Verónica Casquero-García, Silvia García-Cobos, José Antonio Lepe, Enrique Ruiz de Gopegui Bordes, Jorge Calvo-Montes, Nieves Larrosa Escartín, Rafael Cantón, María Pérez-Vázquez, Belén Aracil, Jesús Oteo-Iglesias |
| Source: |
Frontiers in Microbiology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Microbiology |
| Subject Terms: |
Staphylococcus aureus, macrolides, ST398, ermT, EARS-Net, antibiotic resistance, Microbiology, QR1-502 |
| More Details: |
ObjectivesTo describe and analyse erythromycin resistance trends in blood isolates of Staphylococcus aureus (EARS-Net Spain, 2004–2020) and the association of these trends with the consumption of macrolide, lincosamide, and streptogramin B (MLSB) antibiotics. To assess molecular changes that could be involved in erythromycin resistance trends by whole genome analysis of representative isolates.Materials and methodsWe collected antibiotic susceptibility data for all first-blood S. aureus isolates in patients from 47 Spanish hospitals according to EARS-Net criteria. MLSB antibiotic consumption was obtained from the Spanish Agency for Medicines and Medical Devices (2008–2020). We sequenced 137 representative isolates for core genome multilocus sequence typing, resistome and virulome analysis.ResultsFor the 36,612 invasive S. aureus isolates, methicillin resistance decreased from 26.4% in 2004 to 22.4% in 2020. Erythromycin resistance in methicillin-susceptible S. aureus (MSSA) increased from 13.6% in 2004 to 28.9% in 2020 (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-302X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fmicb.2023.1220286/full; https://doaj.org/toc/1664-302X |
| DOI: |
10.3389/fmicb.2023.1220286 |
| Access URL: |
https://doaj.org/article/a6d30d71860a4371879ec69660d90f98 |
| Accession Number: |
edsdoj.6d30d71860a4371879ec69660d90f98 |
| Database: |
Directory of Open Access Journals |
