Bibliographic Details
| Title: |
Association between humoral serological markers levels and risk of SARS-CoV-2 infection after the primary COVID-19 vaccine course among ANRS0001S COV-POPART cohort participants |
| Authors: |
Mathieu Chalouni, Paul Loubet, Edouard Lhomme, Laetitia Ninove, Benoit Barrou, Jean-Yves Blay, Maryvonne Hourmant, Jérome de Seze, Martine Laville, Bruno Laviolle, Jean-Daniel Lelièvre, Jacques Morel, Stéphanie Nguyen Quoc, Jean-Philippe Spano, Benjamin Terrier, Anne Thiebaut, Jean-Francois Viallard, François Vrtovsnik, Sophie Circosta, Aude Barquin, Mariam Gharib, Eric Tartour, Béatrice Parfait, Rodolphe Thiébaut, Laurence Meyer, Xavier de Lamballerie, Odile Launay, Linda Wittkop, for the ANRS0001S COV-POPART study group |
| Source: |
BMC Infectious Diseases, Vol 24, Iss 1, Pp 1-11 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Specific populations, SARS-CoV-2, Vaccine, Prediction, Infectious and parasitic diseases, RC109-216 |
| More Details: |
Abstract Background We assessed the prognostic value of serological humoral markers measured one month after the last dose of the primary COVID-19 vaccine course for predicting the risk of severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection over the following six months in specific populations. Methods ANRS0001SCOV-POPART is a French nationwide multicenter prospective observational cohort study assessing the immune response to Covid-19 vaccines routinely administered to 11 subgroups of patients with chronic disease and a control group. Participants from the ANRS0001S COV-POPART were included if they received at least two doses of Covid-19 vaccine for the primary vaccine course, had measurements of anti-Spike, anti-receptor binding domain (RBD) IgG-specific or neutralizing antibodies one month after the end of the primary vaccine course, without being infected by SARS-CoV-2 before the measurement. SARS-CoV-2 infections defined by a positive PCR/antigenic test or seroconversion to detectable anti nucleocapsid antibodies were evaluated until the first COVID-19 booster injection. Cox proportional hazards models taking into account interval-censored data were implemented to estimate the association between each antibody level and the risk of SARS-CoV-2 infection. Predictive performances were evaluated by the area under the receiving operating characteristic curve (AUROC). Results Two thousand five hundred seventy adults from a specific population and 1,123 from the control group were included. The cumulative probabilities of SARS-CoV-2 infections at five months after serological measurement were 6.0% 95% confidence interval: [5.0; 7.9] and 10.1% 95% confidence interval: [8.3; 11.9], respectively. Higher levels of anti-Spike IgG antibody were associated with a lower risk of SARS-CoV-2 infections in the control group, but not in the specific populations. Among the specific populations, AUROC were 74.5%, 74.9%, and 72.4% for anti-Spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. AUROC were superior in the specific populations, 82.0%, 81.2%, and 81.4% for anti-Spike IgG, anti-RBD IgG, and neutralizing antibodies, respectively. Conclusions Vaccine-induced antibody response after the primary course of Covid-19 infection only moderately discriminated between participants developing a SARS-CoV-2 infection during the Omicron wave. Trial registration NCT04824651 (first posted: 2021-04-01). |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-2334 |
| Relation: |
https://doaj.org/toc/1471-2334 |
| DOI: |
10.1186/s12879-024-09861-5 |
| Access URL: |
https://doaj.org/article/6cff1b58503d4e3faa94651a0db1e461 |
| Accession Number: |
edsdoj.6cff1b58503d4e3faa94651a0db1e461 |
| Database: |
Directory of Open Access Journals |
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