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Circulating adenoid cystic carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies

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Title: Circulating adenoid cystic carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies
Authors: Acadia H.M. Moeyersoms, Kendall W. Knechtel, Andrew J. Rong, Ryan A. Gallo, Michelle Zhang, Harper M. Marsh, Zoukaa B. Sargi, Jason M. Leibowitz, Francisco J. Civantos, Donald T. Weed, Sander R. Dubovy, David T. Tse, Daniel Pelaez
Source: The Journal of Liquid Biopsy, Vol 6, Iss , Pp 100276- (2024)
Publisher Information: Elsevier, 2024.
Publication Year: 2024
Collection: LCC:Medicine
Subject Terms: Adenoid cystic carcinoma, Rare cancer, MYB, Liquid biopsy, Diagnostic biomarkers, Medicine
More Details: Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head and neck. A prominent molecular feature of ACC is the overexpression of the proto-oncogene MYB. ACC has a poor long-term survival due to its high propensity for recurrence and protracted metastasis. Currently, clinical technologies lack the efficiency to distinguish patient prognosis prior to its redevelopment. We hypothesize that metastatic ACC can be detected by monitoring tumor-specific MYB expression in patients’ blood. We developed a quantitative polymerase chain reaction (qPCR) assay for MYB transcripts and screened blood samples from four patient cohorts: no history or evidence of ACC (n = 23), past history of ACC and no evidence of disease (NED) for greater than three years (n = 15), local ACC (n = 6), and metastatic ACC (n = 5). Our assay detected significantly elevated levels of MYB transcripts in the metastatic ACC cohort (p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2950-1954
Relation: http://www.sciencedirect.com/science/article/pii/S2950195424001425; https://doaj.org/toc/2950-1954
DOI: 10.1016/j.jlb.2024.100276
Access URL: https://doaj.org/article/6cf1060af1784a5583515f814fe0af75
Accession Number: edsdoj.6cf1060af1784a5583515f814fe0af75
Database: Directory of Open Access Journals
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  Data: Circulating adenoid cystic carcinoma associated MYB transcripts enable rapid and sensitive detection of metastatic disease in blood liquid biopsies
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  Data: <searchLink fieldCode="AR" term="%22Acadia+H%2EM%2E+Moeyersoms%22">Acadia H.M. Moeyersoms</searchLink><br /><searchLink fieldCode="AR" term="%22Kendall+W%2E+Knechtel%22">Kendall W. Knechtel</searchLink><br /><searchLink fieldCode="AR" term="%22Andrew+J%2E+Rong%22">Andrew J. Rong</searchLink><br /><searchLink fieldCode="AR" term="%22Ryan+A%2E+Gallo%22">Ryan A. Gallo</searchLink><br /><searchLink fieldCode="AR" term="%22Michelle+Zhang%22">Michelle Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Harper+M%2E+Marsh%22">Harper M. Marsh</searchLink><br /><searchLink fieldCode="AR" term="%22Zoukaa+B%2E+Sargi%22">Zoukaa B. Sargi</searchLink><br /><searchLink fieldCode="AR" term="%22Jason+M%2E+Leibowitz%22">Jason M. Leibowitz</searchLink><br /><searchLink fieldCode="AR" term="%22Francisco+J%2E+Civantos%22">Francisco J. Civantos</searchLink><br /><searchLink fieldCode="AR" term="%22Donald+T%2E+Weed%22">Donald T. Weed</searchLink><br /><searchLink fieldCode="AR" term="%22Sander+R%2E+Dubovy%22">Sander R. Dubovy</searchLink><br /><searchLink fieldCode="AR" term="%22David+T%2E+Tse%22">David T. Tse</searchLink><br /><searchLink fieldCode="AR" term="%22Daniel+Pelaez%22">Daniel Pelaez</searchLink>
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  Data: The Journal of Liquid Biopsy, Vol 6, Iss , Pp 100276- (2024)
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  Data: Elsevier, 2024.
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  Data: 2024
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  Data: <searchLink fieldCode="DE" term="%22Adenoid+cystic+carcinoma%22">Adenoid cystic carcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22Rare+cancer%22">Rare cancer</searchLink><br /><searchLink fieldCode="DE" term="%22MYB%22">MYB</searchLink><br /><searchLink fieldCode="DE" term="%22Liquid+biopsy%22">Liquid biopsy</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+biomarkers%22">Diagnostic biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
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  Data: Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head and neck. A prominent molecular feature of ACC is the overexpression of the proto-oncogene MYB. ACC has a poor long-term survival due to its high propensity for recurrence and protracted metastasis. Currently, clinical technologies lack the efficiency to distinguish patient prognosis prior to its redevelopment. We hypothesize that metastatic ACC can be detected by monitoring tumor-specific MYB expression in patients’ blood. We developed a quantitative polymerase chain reaction (qPCR) assay for MYB transcripts and screened blood samples from four patient cohorts: no history or evidence of ACC (n = 23), past history of ACC and no evidence of disease (NED) for greater than three years (n = 15), local ACC (n = 6), and metastatic ACC (n = 5). Our assay detected significantly elevated levels of MYB transcripts in the metastatic ACC cohort (p
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      – SubjectFull: Adenoid cystic carcinoma
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      – SubjectFull: Rare cancer
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      – SubjectFull: MYB
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