Bibliographic Details
| Title: |
Generation of human induced pluripotent stem cell (hiPSC) lines from patients with extreme high and low polygenic scores for QT interval |
| Authors: |
Devyn Mitchell, Rizwan Ullah, Loren Vanags, Alex Shen, Luke Jones, William Morris, Matthew J. O’Neill, Giovanni Davogustto, Christian Shaffer, Dan Roden, Ben Shoemaker, Hollie Williams, Teresa Strickland, Taylor Agee, Christopher Johnson, Brett Kroncke |
| Source: |
Stem Cell Research, Vol 84, Iss , Pp 103691- (2025) |
| Publisher Information: |
Elsevier, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
Biology (General), QH301-705.5 |
| More Details: |
Long QT syndrome (LQTS), an inherited cardiac arrhythmia syndrome with congenital and drug-induced presentations and known monogenic and polygenic contributions, represents a significant clinical challenge due to its complex genetic underpinning and propensity for fatal arrhythmias. In this study, we generated induced pluripotent stem cells (iPSCs) reprogrammed from peripheral blood mononuclear cells (PBMCs) of six patients with extreme polygenic scores for short and long corrected QT intervals. This patient-specific approach will enable us to better understand variable expressivity and penetrance of LQTS, using rigorously validated iPSC lines serve as a vital resource for elucidating the molecular mechanisms underlying LQTS. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1873-5061 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1873506125000418; https://doaj.org/toc/1873-5061 |
| DOI: |
10.1016/j.scr.2025.103691 |
| Access URL: |
https://doaj.org/article/6cd9f0ef0cc8439cbdaee56c97557115 |
| Accession Number: |
edsdoj.6cd9f0ef0cc8439cbdaee56c97557115 |
| Database: |
Directory of Open Access Journals |
