Bibliographic Details
| Title: |
Anorectal malformations (ARM) and VACTERL association and severity of congenital heart diseases (CHD): Experience of 396 consecutive patients in a tertiary center |
| Authors: |
Patrizio Moras, Angelo Zarfati, Pietro Bagolan, Andrea Conforti, Alessandra Toscano, Barbara Daniela Iacobelli |
| Source: |
Pediatrics and Neonatology, Vol 65, Iss 4, Pp 381-385 (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Pediatrics |
| Subject Terms: |
Anorectal malformations, ARM, VACTERL, VACTERL association, Congenital heart disease, CHD, Pediatrics, RJ1-570 |
| More Details: |
Objective: Congenital heart diseases (CHD) are the most frequently associated anomalies with anorectal malformations (ARM). Nevertheless, many specific aspects of CHD in ARM patients have yet to be studied. The aims of this study were to evaluate the prevalence and distribution of CHD in neonates-infants with ARM, and to explore whether the severity of ARM, and the presence of VACTERL association, had an impact on CHD rate, severity, and timing at first cardiac surgery. Study design: All consecutive newborn-infants with ARM managed in our tertiary center (January-1999; December-2021) were collected from a prospective database and retrospectively analyzed. Prevalence and distribution of CHD in ARM patients were assessed. Patients were divided into groups depending on ARM severity and presence of VACTERL association. Pairwise comparison for CHD prevalence, severity, and timing at first cardiac surgery was performed between groups. Results: Of 396 ARM patients identified, those with severe ARM showed a higher number of overall CHD compared to patients with non-severe ARM (36.7 % vs. 25.2 %, p = 0.032). VACTERL + patients had a significantly higher prevalence of CHD (73.4 % vs. 16.4 %; p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1875-9572 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1875957223002243; https://doaj.org/toc/1875-9572 |
| DOI: |
10.1016/j.pedneo.2023.08.011 |
| Access URL: |
https://doaj.org/article/6cc5c1ccbaf1421ebd23d1f64cf675c8 |
| Accession Number: |
edsdoj.6cc5c1ccbaf1421ebd23d1f64cf675c8 |
| Database: |
Directory of Open Access Journals |
