Academic Journal
Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks
| Title: | Association between dynamic resting-state functional connectivity and ketamine plasma levels in visual processing networks |
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| Authors: | Marie Spies, Manfred Klöbl, Anna Höflich, Allan Hummer, Thomas Vanicek, Paul Michenthaler, Georg S. Kranz, Andreas Hahn, Dietmar Winkler, Christian Windischberger, Siegfried Kasper, Rupert Lanzenberger |
| Source: | Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019) |
| Publisher Information: | Nature Portfolio, 2019. |
| Publication Year: | 2019 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Numerous studies demonstrate ketamine’s influence on resting-state functional connectivity (rsFC). Seed-based and static rsFC estimation methods may oversimplify FC. These limitations can be addressed with whole-brain, dynamic rsFC estimation methods. We assessed data from 27 healthy subjects who underwent two 3 T resting-state fMRI scans, once under subanesthetic, intravenous esketamine and once under placebo, in a randomized, cross-over manner. We aimed to isolate only highly robust effects of esketamine on dynamic rsFC by using eight complementary methodologies derived from two dynamic rsFC estimation methods, two functionally defined atlases and two statistical measures. All combinations revealed a negative influence of esketamine on dynamic rsFC within the left visual network and inter-hemispherically between visual networks (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-019-46702-x |
| Access URL: | https://doaj.org/article/dc6ca1232e844b7e87ff334666da85ae |
| Accession Number: | edsdoj.6ca1232e844b7e87ff334666da85ae |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-019-46702-x |
| Published in: | Scientific Reports |
| Language: | English |