Bibliographic Details
| Title: |
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum |
| Authors: |
Chiara Bruzzone, Maider Bizkarguenaga, Rubén Gil-Redondo, Tammo Diercks, Eunate Arana, Aitor García de Vicuña, Marisa Seco, Alexandre Bosch, Asís Palazón, Itxaso San Juan, Ana Laín, Jon Gil-Martínez, Ganeko Bernardo-Seisdedos, David Fernández-Ramos, Fernando Lopitz-Otsoa, Nieves Embade, Shelly Lu, José M. Mato, Oscar Millet |
| Source: |
iScience, Vol 23, Iss 10, Pp 101645- (2020) |
| Publisher Information: |
Elsevier, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Human Metabolism, Virology, Metabolomics, Science |
| More Details: |
Summary: COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004220308373; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2020.101645 |
| Access URL: |
https://doaj.org/article/6c94517cdfc74dbc8bca49abed3a345f |
| Accession Number: |
edsdoj.6c94517cdfc74dbc8bca49abed3a345f |
| Database: |
Directory of Open Access Journals |
