Academic Journal
Interconnectivity between molecular subtypes and tumor stage in colorectal cancer
| Title: | Interconnectivity between molecular subtypes and tumor stage in colorectal cancer |
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| Authors: | R. R. J. Coebergh van den Braak, S. ten Hoorn, A. M. Sieuwerts, J. B. Tuynman, M. Smid, S. M. Wilting, J. W. M. Martens, C. J. A. Punt, J. A. Foekens, J. P. Medema, J. N. M. IJzermans, L. Vermeulen |
| Source: | BMC Cancer, Vol 20, Iss 1, Pp 1-7 (2020) |
| Publisher Information: | BMC, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Colorectal cancer, Molecular subtype, Tumor biology, CMS, TNM, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Background There are profound individual differences in clinical outcomes between colorectal cancers (CRCs) presenting with identical stage of disease. Molecular stratification, in conjunction with the traditional TNM staging, is a promising way to predict patient outcomes. We investigated the interconnectivity between tumor stage and tumor biology reflected by the Consensus Molecular Subtypes (CMSs) in CRC, and explored the possible value of these insights in patients with stage II colon cancer. Methods We performed a retrospective analysis using clinical records and gene expression profiling in a meta-cohort of 1040 CRC patients. The interconnectivity of tumor biology and disease stage was assessed by investigating the association between CMSs and TNM classification. In order to validate the clinical applicability of our findings we employed a meta-cohort of 197 stage II colon cancers. Results CMS4 was significantly more prevalent in advanced stages of disease (stage I 9.8% versus stage IV 38.5%, p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1471-2407 41438035 |
| Relation: | http://link.springer.com/article/10.1186/s12885-020-07316-z; https://doaj.org/toc/1471-2407 |
| DOI: | 10.1186/s12885-020-07316-z |
| Access URL: | https://doaj.org/article/d6c7c6e7e2db4724b5be3c4143803535 |
| Accession Number: | edsdoj.6c7c6e7e2db4724b5be3c4143803535 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14712407 41438035 |
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| DOI: | 10.1186/s12885-020-07316-z |
| Published in: | BMC Cancer |
| Language: | English |