Academic Journal
Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma
| Title: | Morphogenetic and Imaging Characteristics in Giant Cell Glioblastoma |
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| Authors: | Cristian Ionut Orasanu, Mariana Aschie, Mariana Deacu, Liliana Mocanu, Raluca Ioana Voda, Theodor Sebastian Topliceanu, Georgeta Camelia Cozaru |
| Source: | Current Oncology, Vol 29, Iss 8, Pp 5316-5323 (2022) |
| Publisher Information: | MDPI AG, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | CDKN2A, giant cell glioblastoma, imaging, immunohistochemistry, TP53, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Giant cell glioblastoma is a rare tumor entity of IDH-wildtype glioblastoma. It is usually found in the pediatric population. We describe a particular case of a female patient diagnosed histopathologically with giant cell glioblastoma, who had two recurrences in different lobes of the same cerebral hemisphere, despite positive prognostic factors and appropriate treatment. We performed an immunohistochemical characterization of giant cell glioblastoma as well as an analysis of its aggressiveness using the cytogenetic markers TP53, CDKN2A, and TP73 using the FISH technique. The clinical picture was inconsistant, the suspicion being completely different initially. Paraclinical examination and imaging initially suggested a metastasis to the insular lobe. After surgery, histopathological and immunohistochemical examinations were the basis for the diagnosis. Despite the prognostic factors known so far in the literature, the aggressiveness denoted by multiple relapses and morphogenetic tests particularizes the case and improves the literature by bringing new information about this rare neoplasm of the central nervous system. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1718-7729 1198-0052 33010048 |
| Relation: | https://www.mdpi.com/1718-7729/29/8/422; https://doaj.org/toc/1198-0052; https://doaj.org/toc/1718-7729 |
| DOI: | 10.3390/curroncol29080422 |
| Access URL: | https://doaj.org/article/6c33010048e54df6891f3982323fca07 |
| Accession Number: | edsdoj.6c33010048e54df6891f3982323fca07 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 17187729 11980052 33010048 |
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| DOI: | 10.3390/curroncol29080422 |
| Published in: | Current Oncology |
| Language: | English |