Antineoplastic properties of polyphenols in TPC-1 human papillary thyroid carcinoma cell line: a systematic review

Bibliographic Details
Title: Antineoplastic properties of polyphenols in TPC-1 human papillary thyroid carcinoma cell line: a systematic review
Authors: Marielle Lang Makiyama, Maria Júlia Pigatti Degli Esposti, Maria Luíza Raitz Siqueira, Margarete Dulce Bagatini, Sarah Franco Vieira de Oliveira Maciel, Marcelo Moreno
Source: Archives of Endocrinology and Metabolism, Vol 67, Iss 6 (2023)
Publisher Information: Brazilian Society of Endocrinology and Metabolism, 2023.
Publication Year: 2023
Collection: LCC:Medicine
LCC:Diseases of the endocrine glands. Clinical endocrinology
Subject Terms: TPC-1, polyphenols, thyroid cancer, papillary thyroid cancer, Medicine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
More Details: ABSTRACT Thyroid cancer usually responds to surgical and ablative therapy, but when it's refractory the alternative lies in tyrosine kinase inhibitors that, in addition to harmful side effects, acts only in a palliative way. The concern for other therapeutic possibilities brought evidence on flavonoids, hypothesizing a possible strategy. This review aimed to organize a compilation of in vitro studies using polyphenol substances in TPC-1 (human papillary thyroid carcinoma cell line) summarizing it's results and describing the metabolic pathways involved. Articles were selected on PubMed, Google Scholar, LILACS, BVS and SciELO, using keywords “thyroid cancer”, “flavonoids” and “TPC-1”, until June 2022. 185 studies were selected. After identification and exclusion of duplicates and exclusion criteria applied, 11 original articles were evaluated. Of these, the findings of flavonoids added to TPC-1 were: inhibition of cell growth and viability, promotion of cell cycle arrest and induction of apoptosis. Polyphenolic compounds have antineoplastic properties by different mechanisms as shown in vitro, but the concentrations needed are above usual dietary consumption and the findings are limited to experimental cellular studies. Despite that, these results should be useful to guide further analysis aiming to reveal the real safety and efficacy of polyphenols in this scenario.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2359-4292
2359-3997
Relation: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972023000600302&lng=en&tlng=en; http://www.scielo.br/pdf/aem/v67n6/2359-4292-aem-67-06-e000645.pdf; https://doaj.org/toc/2359-4292
DOI: 10.20945/2359-3997000000645
Access URL: https://doaj.org/article/ee6c162e488c4a049393a48a4c6accc0
Accession Number: edsdoj.6c162e488c4a049393a48a4c6accc0
Database: Directory of Open Access Journals
More Details
ISSN:23594292
23593997
DOI:10.20945/2359-3997000000645
Published in:Archives of Endocrinology and Metabolism
Language:English