| Title: |
The Role of SIRT1 in Vascular Cognitive Impairment |
| Authors: |
YANG Xinyu, LI Yanjie, QIN Hewei, LIU Dandan, ZHAO Nannan, JIANG Jingjing |
| Source: |
Xiehe Yixue Zazhi, Vol 15, Iss 5, Pp 1124-1130 (2024) |
| Publisher Information: |
Editorial Office of Medical Journal of Peking Union Medical College Hospital, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
vascular cognitive impairment, sirtuin 1, neuroinflammation, oxidative stress, Medicine |
| More Details: |
Vascular cognitive impairment (VCI) denotes a wide range of cognitive deficiencies resulting from cerebrovascular risk factors and cerebrovascular diseases. Sirtuin 1 (SIRT1), as a deacetylase, can mediate the deacetylation of histones and non-histone proteins. It is involved in regulating multiple pathophysiological processes of VCI, including neuroinflammation reduction, oxidative stress inhibition, cell apoptosis decrease, and blood-brain barrier protection, serving as a target for VCI treatment. This paper summarizes SIRT1 and the molecular mechanisms of targeting SIRT1 in order to provide a reference for the clinical treatment of VCI. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
Chinese |
| ISSN: |
1674-9081 |
| Relation: |
https://doaj.org/toc/1674-9081 |
| DOI: |
10.12290/xhyxzz.2024-0062 |
| Access URL: |
https://doaj.org/article/6c07c27abc0d471abb0128e533dc53f8 |
| Accession Number: |
edsdoj.6c07c27abc0d471abb0128e533dc53f8 |
| Database: |
Directory of Open Access Journals |
