Academic Journal
Frontier applications of retinal nanomedicine: progress, challenges and perspectives
| Title: | Frontier applications of retinal nanomedicine: progress, challenges and perspectives |
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| Authors: | Zhimin Tang, Fuxiang Ye, Ni Ni, Xianqun Fan, Linna Lu, Ping Gu |
| Source: | Journal of Nanobiotechnology, Vol 23, Iss 1, Pp 1-50 (2025) |
| Publisher Information: | BMC, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Biotechnology LCC:Medical technology |
| Subject Terms: | Retinal diseases, Nanomedicine, Eye drop, Therapeutic nanoagents, Theranostic, Gene therapy, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5 |
| More Details: | Abstract The human retina is a fragile and sophisticated light-sensitive tissue in the central nervous system. Unhealthy retinas can cause irreversible visual deterioration and permanent vision loss. Effective therapeutic strategies are restricted to the treatment or reversal of these conditions. In recent years, nanoscience and nanotechnology have revolutionized targeted management of retinal diseases. Pharmaceuticals, theranostics, regenerative medicine, gene therapy, and retinal prostheses are indispensable for retinal interventions and have been significantly advanced by nanomedical innovations. Hence, this review presents novel insights into the use of versatile nanomaterial-based nanocomposites for frontier retinal applications, including non-invasive drug delivery, theranostic contrast agents, therapeutic nanoagents, gene therapy, stem cell-based therapy, retinal optogenetics and retinal prostheses, which have mainly been reported within the last 5 years. Furthermore, recent progress, potential challenges, and future perspectives in this field are highlighted and discussed in detail, which may shed light on future clinical translations and ultimately, benefit patients with retinal disorders. Graphical Abstract |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1477-3155 |
| Relation: | https://doaj.org/toc/1477-3155 |
| DOI: | 10.1186/s12951-025-03095-6 |
| Access URL: | https://doaj.org/article/6be646fa2905414c9ea6908d47bdeb5f |
| Accession Number: | edsdoj.6be646fa2905414c9ea6908d47bdeb5f |
| Database: | Directory of Open Access Journals |
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| ISSN: | 14773155 |
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| DOI: | 10.1186/s12951-025-03095-6 |
| Published in: | Journal of Nanobiotechnology |
| Language: | English |