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Differential Diagnosis of Stroke by Platelet Large Cell Ratio (P-LCR) Levels

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Title: Differential Diagnosis of Stroke by Platelet Large Cell Ratio (P-LCR) Levels
Authors: Mehmet Nuri Koçak, Mustafa Bayraktar, Erdal Tekin, Muhammet Çelik
Source: Journal of Contemporary Medicine, Vol 11, Iss 6, Pp 900-904 (2021)
Publisher Information: Rabia Yılmaz, 2021.
Publication Year: 2021
Collection: LCC:Medicine
Subject Terms: platelet large cell ratio, stroke, ischemic, hemorrhagic, transient ischemic attack, trombosit büyük hücre oranı, i̇nme, i̇skemik, hemorajik, geçici i̇skemik atak, Medicine
More Details: Aim: Platelets play an important role in the pathogenesis of thrombosis and atherosclerosis. Platelet Large Cell Ratio (P-LCR), a routine hemogram parameter, is the largest fraction of platelets that are more closely related to thrombotic events. In this study, for the first time in the literature, P-LCR levels in ischemic and hemorrhagic stroke patients were compared with the levels in transient ischemic attack (TIA) group. Method: Retrospectively, hospital records between January 2016 and 2019, were searched by ICD-10 codes, and patients aged between 18-70 years who were diagnosed as ischemic stroke, hemorrhagic stroke and transient ischemic attack were included. The P-LCR test results in the first hemogram test of the patients taken at the time of admission to the hospital were included and compared. Results: Of the 4511 patients, 92.6% (n=4177) were diagnosed with ischemic stroke, 6% (n=271) with hemorrhagic stroke, and 1.4% (n=63) of patients with TIA. The P-LCR levels of the ischemic and hemorrhagic stroke patients were found to be significantly higher than the TIA group (p=0.027; p=0.044, respectively). The Area Under the Curve (AUC) values for ischemic, hemorrhagic and total stroke versus TIA patients were 0.581, 0.568, and 0.580; respectively. The cut-off value of P-LCR was 26.65 ng/L between the ischemic stroke and TIA. Conclusion: The increase in P-LCR levels can be used to distinguish ischemic and hemorrhagic stroke from TIA.
Document Type: article
File Description: electronic resource
Language: English
Turkish
ISSN: 2667-7180
Relation: https://dergipark.org.tr/tr/download/article-file/1529407; https://doaj.org/toc/2667-7180
DOI: 10.16899/jcm.867170
Access URL: https://doaj.org/article/6b2f2c0ba7ef4ef08d7f7e60b7d6c5e1
Accession Number: edsdoj.6b2f2c0ba7ef4ef08d7f7e60b7d6c5e1
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  Data: Differential Diagnosis of Stroke by Platelet Large Cell Ratio (P-LCR) Levels
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Mehmet+Nuri+Koçak%22">Mehmet Nuri Koçak</searchLink><br /><searchLink fieldCode="AR" term="%22Mustafa+Bayraktar%22">Mustafa Bayraktar</searchLink><br /><searchLink fieldCode="AR" term="%22Erdal+Tekin%22">Erdal Tekin</searchLink><br /><searchLink fieldCode="AR" term="%22Muhammet+Çelik%22">Muhammet Çelik</searchLink>
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  Data: Journal of Contemporary Medicine, Vol 11, Iss 6, Pp 900-904 (2021)
– Name: Publisher
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  Data: Rabia Yılmaz, 2021.
– Name: DatePubCY
  Label: Publication Year
  Group: Date
  Data: 2021
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  Label: Collection
  Group: HoldingsInfo
  Data: LCC:Medicine
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  Label: Subject Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22platelet+large+cell+ratio%22">platelet large cell ratio</searchLink><br /><searchLink fieldCode="DE" term="%22stroke%22">stroke</searchLink><br /><searchLink fieldCode="DE" term="%22ischemic%22">ischemic</searchLink><br /><searchLink fieldCode="DE" term="%22hemorrhagic%22">hemorrhagic</searchLink><br /><searchLink fieldCode="DE" term="%22transient+ischemic+attack%22">transient ischemic attack</searchLink><br /><searchLink fieldCode="DE" term="%22trombosit+büyük+hücre+oranı%22">trombosit büyük hücre oranı</searchLink><br /><searchLink fieldCode="DE" term="%22i̇nme%22">i̇nme</searchLink><br /><searchLink fieldCode="DE" term="%22i̇skemik%22">i̇skemik</searchLink><br /><searchLink fieldCode="DE" term="%22hemorajik%22">hemorajik</searchLink><br /><searchLink fieldCode="DE" term="%22geçici+i̇skemik+atak%22">geçici i̇skemik atak</searchLink><br /><searchLink fieldCode="DE" term="%22Medicine%22">Medicine</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: Aim: Platelets play an important role in the pathogenesis of thrombosis and atherosclerosis. Platelet Large Cell Ratio (P-LCR), a routine hemogram parameter, is the largest fraction of platelets that are more closely related to thrombotic events. In this study, for the first time in the literature, P-LCR levels in ischemic and hemorrhagic stroke patients were compared with the levels in transient ischemic attack (TIA) group. Method: Retrospectively, hospital records between January 2016 and 2019, were searched by ICD-10 codes, and patients aged between 18-70 years who were diagnosed as ischemic stroke, hemorrhagic stroke and transient ischemic attack were included. The P-LCR test results in the first hemogram test of the patients taken at the time of admission to the hospital were included and compared. Results: Of the 4511 patients, 92.6% (n=4177) were diagnosed with ischemic stroke, 6% (n=271) with hemorrhagic stroke, and 1.4% (n=63) of patients with TIA. The P-LCR levels of the ischemic and hemorrhagic stroke patients were found to be significantly higher than the TIA group (p=0.027; p=0.044, respectively). The Area Under the Curve (AUC) values for ischemic, hemorrhagic and total stroke versus TIA patients were 0.581, 0.568, and 0.580; respectively. The cut-off value of P-LCR was 26.65 ng/L between the ischemic stroke and TIA. Conclusion: The increase in P-LCR levels can be used to distinguish ischemic and hemorrhagic stroke from TIA.
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  Data: 10.16899/jcm.867170
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RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.16899/jcm.867170
    Languages:
      – Text: English
      – Text: Turkish
    PhysicalDescription:
      Pagination:
        PageCount: 5
        StartPage: 900
    Subjects:
      – SubjectFull: platelet large cell ratio
        Type: general
      – SubjectFull: stroke
        Type: general
      – SubjectFull: ischemic
        Type: general
      – SubjectFull: hemorrhagic
        Type: general
      – SubjectFull: transient ischemic attack
        Type: general
      – SubjectFull: trombosit büyük hücre oranı
        Type: general
      – SubjectFull: i̇nme
        Type: general
      – SubjectFull: i̇skemik
        Type: general
      – SubjectFull: hemorajik
        Type: general
      – SubjectFull: geçici i̇skemik atak
        Type: general
      – SubjectFull: Medicine
        Type: general
    Titles:
      – TitleFull: Differential Diagnosis of Stroke by Platelet Large Cell Ratio (P-LCR) Levels
        Type: main
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          Name:
            NameFull: Mehmet Nuri Koçak
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            NameFull: Mustafa Bayraktar
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            NameFull: Erdal Tekin
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            NameFull: Muhammet Çelik
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            – D: 01
              M: 11
              Type: published
              Y: 2021
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              Value: 11
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              Value: 6
          Titles:
            – TitleFull: Journal of Contemporary Medicine
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