Differential Diagnosis of Stroke by Platelet Large Cell Ratio (P-LCR) Levels
| Title: | Differential Diagnosis of Stroke by Platelet Large Cell Ratio (P-LCR) Levels |
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| Authors: | Mehmet Nuri Koçak, Mustafa Bayraktar, Erdal Tekin, Muhammet Çelik |
| Source: | Journal of Contemporary Medicine, Vol 11, Iss 6, Pp 900-904 (2021) |
| Publisher Information: | Rabia Yılmaz, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medicine |
| Subject Terms: | platelet large cell ratio, stroke, ischemic, hemorrhagic, transient ischemic attack, trombosit büyük hücre oranı, i̇nme, i̇skemik, hemorajik, geçici i̇skemik atak, Medicine |
| More Details: | Aim: Platelets play an important role in the pathogenesis of thrombosis and atherosclerosis. Platelet Large Cell Ratio (P-LCR), a routine hemogram parameter, is the largest fraction of platelets that are more closely related to thrombotic events. In this study, for the first time in the literature, P-LCR levels in ischemic and hemorrhagic stroke patients were compared with the levels in transient ischemic attack (TIA) group. Method: Retrospectively, hospital records between January 2016 and 2019, were searched by ICD-10 codes, and patients aged between 18-70 years who were diagnosed as ischemic stroke, hemorrhagic stroke and transient ischemic attack were included. The P-LCR test results in the first hemogram test of the patients taken at the time of admission to the hospital were included and compared. Results: Of the 4511 patients, 92.6% (n=4177) were diagnosed with ischemic stroke, 6% (n=271) with hemorrhagic stroke, and 1.4% (n=63) of patients with TIA. The P-LCR levels of the ischemic and hemorrhagic stroke patients were found to be significantly higher than the TIA group (p=0.027; p=0.044, respectively). The Area Under the Curve (AUC) values for ischemic, hemorrhagic and total stroke versus TIA patients were 0.581, 0.568, and 0.580; respectively. The cut-off value of P-LCR was 26.65 ng/L between the ischemic stroke and TIA. Conclusion: The increase in P-LCR levels can be used to distinguish ischemic and hemorrhagic stroke from TIA. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Turkish |
| ISSN: | 2667-7180 |
| Relation: | https://dergipark.org.tr/tr/download/article-file/1529407; https://doaj.org/toc/2667-7180 |
| DOI: | 10.16899/jcm.867170 |
| Access URL: | https://doaj.org/article/6b2f2c0ba7ef4ef08d7f7e60b7d6c5e1 |
| Accession Number: | edsdoj.6b2f2c0ba7ef4ef08d7f7e60b7d6c5e1 |
| Database: | Directory of Open Access Journals |
| ISSN: | 26677180 |
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| DOI: | 10.16899/jcm.867170 |
| Published in: | Journal of Contemporary Medicine |
| Language: | English Turkish |