| Title: |
Development and validation of a population pharmacokinetic model of vancomycin for patients of advanced age |
| Authors: |
Keisuke Takada, Masaru Samura, Yuki Igarashi, Ayako Suzuki, Tomoyuki Ishigo, Satoshi Fujii, Yuta Ibe, Hiroaki Yoshida, Hiroaki Tanaka, Fumiya Ebihara, Takumi Maruyama, Yukihiro Hamada, Toshiaki Komatsu, Atsushi Tomizawa, Akitoshi Takuma, Hiroaki Chiba, Yusuke Yagi, Yoshifumi Nishi, Yuki Enoki, Kazuaki Taguchi, Koji Tanikawa, Hiroyuki Kunishima, Kazuaki Matsumoto |
| Source: |
Journal of Pharmaceutical Health Care and Sciences, Vol 11, Iss 1, Pp 1-10 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Therapeutics. Pharmacology
LCC:Pharmacy and materia medica |
| Subject Terms: |
Patients of advanced age, Population pharmacokinetics, Serum albumin, Vancomycin, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441 |
| More Details: |
Abstract Background Population pharmacokinetic (PPK) models of vancomycin (VCM) commonly use creatinine clearance (CLcr) as a covariate for clearance (CL). However, relying on CLcr in patients of advanced age may lead to inaccuracies in estimating VCM clearance. Therefore, this study aimed to develop and validate a new PPK model specifically for patients aged 75 years and older. Methods PPK analysis was performed based on the blood concentrations of VCM (n = 159 patients). The predictive performance of the developed model was compared with that of previous models using mean absolute error (MAE) and mean squared error (MSE) for another dataset. Results The PPK analysis optimized a two-compartment model using CLcr and the Alb levels as covariates at the central compartment of VCM clearance. The final model was as follows: CL (L/h) = 1.96 × (CLcr/3.09) 0.63 × (Serum albumin (Alb) /2.3) 0.22 × exponential (0.11). Clearance between the central and peripheral compartments (L/h) = 4.86. Central compartment volume of distribution (L) = 31.78. Peripheral compartment volume of distribution (L) = 53.64. The validation study revealed that compared with those of previous models (ranging from 0.67 to 0.79 L/h and from 0.81 to 1.11 (L/h)2, respectively), the final model demonstrated the smallest MAE of 0.60 L/h and MSE of 0.65 (L/h)2 for patients of advanced age with serum creatinine levels of |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-0294 |
| Relation: |
https://doaj.org/toc/2055-0294 |
| DOI: |
10.1186/s40780-025-00423-8 |
| Access URL: |
https://doaj.org/article/6b09cead7367495eabf7688df0c38aac |
| Accession Number: |
edsdoj.6b09cead7367495eabf7688df0c38aac |
| Database: |
Directory of Open Access Journals |
