Bibliographic Details
| Title: |
PTEN-induced kinase 1 gene single-nucleotide variants as biomarkers in adjuvant chemotherapy for colorectal cancer: a retrospective study |
| Authors: |
Yoshiaki Mihara, Masataka Hirasaki, Yosuke Horita, Takashi Fujino, Hisayo Fukushima, Yasuo Kamakura, Kousuke Uranishi, Yasumitsu Hirano, Shomei Ryozawa, Masanori Yasuda, Yoshinori Makino, Satomi Shibazaki, Tetsuya Hamaguchi |
| Source: |
BMC Gastroenterology, Vol 23, Iss 1, Pp 1-11 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the digestive system. Gastroenterology |
| Subject Terms: |
Colorectal cancer, 5-FU, Adjuvant chemotherapy, Biomarker, PINK1, Diseases of the digestive system. Gastroenterology, RC799-869 |
| More Details: |
Abstract Background Fluoropyrimidine-based postoperative adjuvant chemotherapy is globally recommended for high-risk stage II and stage III colon cancer. However, adjuvant chemotherapy is often associated with severe adverse events and is not highly effective in preventing recurrence. Therefore, discovery of novel molecular biomarkers of postoperative adjuvant chemotherapy to identify patients at increased risk of recurrent colorectal cancer is warranted. Autophagy (including mitophagy) is activated under chemotherapy-induced stress and contributes to chemotherapy resistance. Expression of autophagy-related genes and their single-nucleotide polymorphisms are reported to be effective predictors of chemotherapy response in some cancers. Our goal was to evaluate the relationship between single-nucleotide variants of autophagy-related genes and recurrence rates in order to identify novel biomarkers that predict the effect of adjuvant chemotherapy in colorectal cancer. Methods We analyzed surgical or biopsy specimens from 84 patients who underwent radical surgery followed by fluoropyrimidine-based adjuvant chemotherapy at Saitama Medical University International Medical Center between January and December 2016. Using targeted enrichment sequencing, we identified single-nucleotide variants and insertions/deletions in 50 genes, including autophagy-related genes, and examined their association with colorectal cancer recurrence rates. Results We detected 560 single-nucleotide variants and insertions/deletions in the target region. The results of Fisher’s exact test indicated that the recurrence rate of colorectal cancer after adjuvant chemotherapy was significantly lower in patients with the single-nucleotide variants (c.1018G > A [p C [p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1471-230X |
| Relation: |
https://doaj.org/toc/1471-230X |
| DOI: |
10.1186/s12876-023-02975-1 |
| Access URL: |
https://doaj.org/article/6a5f9b923b2c40fbac8ce5d6d02ba644 |
| Accession Number: |
edsdoj.6a5f9b923b2c40fbac8ce5d6d02ba644 |
| Database: |
Directory of Open Access Journals |
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