Bibliographic Details
| Title: |
Locoregional recurrence after neoadjuvant versus adjuvant chemotherapy based on tumor subtypes in patients with early-stage breast cancer: A multi-institutional retrospective cohort study |
| Authors: |
Jong-Ho Cheun, Youngji Kwak, Eunhye Kang, Ji-Jung Jung, Hong-Kyu Kim, Han-Byoel Lee, Kyung-Hun Lee, Hyeong-Gon Moon, Ki-Tae Hwang, Yeon Hee Park, Jeong Eon Lee, Wonshik Han |
| Source: |
Breast, Vol 78, Iss , Pp 103828- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
Adjuvant chemotherapy, Breast cancer, Breast cancer subtypes, Breast conserving, Locoregional recurrence, Neoadjuvant chemotherapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Background: Neoadjuvant chemotherapy (NACT) for early-stage breast cancer is associated with an increased risk of locoregional recurrence (LRR). We investigated whether the risk of LRR after NACT varies across tumor subtypes. Methods: We retrospectively reviewed the medical records of women who underwent breast-conserving surgery for breast cancer at three institutions between January 1, 2004, and December 31, 2018. Patients received either NACT or adjuvant chemotherapy (ACT), followed by radiotherapy. LRR was analyzed according to the hormone receptor (HR) and human epidermal growth factor receptor-2 (HER2) status using propensity score matching, log-rank test, and Cox regression analysis. Results: Among 10,328 patients, 2479 (24.0 %) received NACT. Within the median follow-up of 84.5 (IQR, 35.1–118.5) months, the 10-year LRR-free survival rates were 94.5 % and 90.7 % for the ACT and NACT groups, respectively (hazard ratio: 2.04, 95 % confidence interval [CI]: 1.68–2.46, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1532-3080 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S0960977624001590; https://doaj.org/toc/1532-3080 |
| DOI: |
10.1016/j.breast.2024.103828 |
| Access URL: |
https://doaj.org/article/69e72bca1dc84536b9d19caab0c3937b |
| Accession Number: |
edsdoj.69e72bca1dc84536b9d19caab0c3937b |
| Database: |
Directory of Open Access Journals |
