Bibliographic Details
| Title: |
Surveillance of Daughter Micronodule Formation Is a Key Factor for Vaccine Evaluation Using Experimental Infection Models of Tuberculosis in Macaques |
| Authors: |
Isabel Nogueira, Martí Català, Andrew D. White, Sally A Sharpe, Jordi Bechini, Clara Prats, Cristina Vilaplana, Pere-Joan Cardona |
| Source: |
Pathogens, Vol 12, Iss 2, p 236 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
tuberculosis, BCG vaccine, aerosol vaccination, non-human primate, macaque, bubble model, Medicine |
| More Details: |
Tuberculosis (TB) is still a major worldwide health problem and models using non-human primates (NHP) provide the most relevant approach for vaccine testing. In this study, we analysed CT images collected from cynomolgus and rhesus macaques following exposure to ultra-low dose Mycobacterium tuberculosis (Mtb) aerosols, and monitored them for 16 weeks to evaluate the impact of prior intradermal or inhaled BCG vaccination on the progression of lung disease. All lesions found (2553) were classified according to their size and we subclassified small micronodules ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-0817 |
| Relation: |
https://www.mdpi.com/2076-0817/12/2/236; https://doaj.org/toc/2076-0817 |
| DOI: |
10.3390/pathogens12020236 |
| Access URL: |
https://doaj.org/article/69aaf39cd93a4d8c87eaa017f48fbc4e |
| Accession Number: |
edsdoj.69aaf39cd93a4d8c87eaa017f48fbc4e |
| Database: |
Directory of Open Access Journals |
