| Title: |
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. |
| Authors: |
John R B Perry, Benjamin F Voight, Loïc Yengo, Najaf Amin, Josée Dupuis, Martha Ganser, Harald Grallert, Pau Navarro, Man Li, Lu Qi, Valgerdur Steinthorsdottir, Robert A Scott, Peter Almgren, Dan E Arking, Yurii Aulchenko, Beverley Balkau, Rafn Benediktsson, Richard N Bergman, Eric Boerwinkle, Lori Bonnycastle, Noël P Burtt, Harry Campbell, Guillaume Charpentier, Francis S Collins, Christian Gieger, Todd Green, Samy Hadjadj, Andrew T Hattersley, Christian Herder, Albert Hofman, Andrew D Johnson, Anna Kottgen, Peter Kraft, Yann Labrune, Claudia Langenberg, Alisa K Manning, Karen L Mohlke, Andrew P Morris, Ben Oostra, James Pankow, Ann-Kristin Petersen, Peter P Pramstaller, Inga Prokopenko, Wolfgang Rathmann, William Rayner, Michael Roden, Igor Rudan, Denis Rybin, Laura J Scott, Gunnar Sigurdsson, Rob Sladek, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Andre G Uitterlinden, Sidonie Vivequin, Michael N Weedon, Alan F Wright, MAGIC, DIAGRAM Consortium, GIANT Consortium, Frank B Hu, Thomas Illig, Linda Kao, James B Meigs, James F Wilson, Kari Stefansson, Cornelia van Duijn, David Altschuler, Andrew D Morris, Michael Boehnke, Mark I McCarthy, Philippe Froguel, Colin N A Palmer, Nicholas J Wareham, Leif Groop, Timothy M Frayling, Stéphane Cauchi |
| Source: |
PLoS Genetics, Vol 8, Iss 5, p e1002741 (2012) |
| Publisher Information: |
Public Library of Science (PLoS), 2012. |
| Publication Year: |
2012 |
| Collection: |
LCC:Genetics |
| Subject Terms: |
Genetics, QH426-470 |
| More Details: |
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1553-7390
1553-7404 |
| Relation: |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22693455/pdf/?tool=EBI; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404 |
| DOI: |
10.1371/journal.pgen.1002741 |
| Access URL: |
https://doaj.org/article/69278706f1ba4c3e8b31e43c60a600aa |
| Accession Number: |
edsdoj.69278706f1ba4c3e8b31e43c60a600aa |
| Database: |
Directory of Open Access Journals |
