Risk factors for chloral hydrate sedation failure in pediatric patients: a retrospective analysis
| Title: | Risk factors for chloral hydrate sedation failure in pediatric patients: a retrospective analysis |
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| Authors: | Young-Eun Jang, Jung-Bin Park, Pyoyoon Kang, Sang-Hwan Ji, Eun-Hee Kim, Ji-Hyun Lee, Hee-Soo Kim, Jin-Tae Kim |
| Source: | Korean Journal of Anesthesiology, Vol 77, Iss 5, Pp 526-536 (2024) |
| Publisher Information: | Korean Society of Anesthesiologists, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Anesthesiology |
| Subject Terms: | chloral hydrate, conscious sedation, deep sedation, drug-related side effects and adverse reactions, hypnotics and sedatives, pediatrics, Anesthesiology, RD78.3-87.3 |
| More Details: | Background This study aimed to investigate the risk factors for chloral hydrate sedation failure and complications in a tertiary children’s hospital in South Korea. Methods A retrospective analysis of pediatric procedural sedation with chloral hydrate between January 1, 2021, and March 30, 2022, was performed. The collected data included patient characteristics, sedation history, and procedure. Multivariable regression analysis was performed to identify the risk factors for procedural sedation failure and complications. Results A total of 6,691 procedural sedation were included in the analysis; sedation failure following chloral hydrate (50 mg/kg) occurred in 1,457 patients (21.8%) and was associated with a higher rate of overall complications compared to those with successful sedation (17.5% [225/1457] vs. 6.2% [322/5234]; P < 0.001, odds ratio: 3.236). In the multivariable regression analysis, the following factors were associated with increased risk of sedation failure: general ward or intensive care unit inpatient (compared with outpatient); congenital syndrome; oxygen dependency; history of sedation failure or complications with chloral hydrate; procedure more than 60 min; and magnetic resonance imaging, radiotherapy, or procedures with painful or intense stimuli (all P values < 0.05). Factors contributing to the complications included general ward inpatient, congenital syndromes, congenital heart disease, preterm birth, oxygen dependency, history of complications with chloral hydrate, and current sedation failure with chloral hydrate (all P values < 0.05). Conclusions To achieve successful sedation with chloral hydrate, the patient’s sedation history, risk factors, and the type and duration of the procedure should be considered. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2005-6419 2005-7563 52107671 |
| Relation: | http://ekja.org/upload/pdf/kja-24125.pdf; https://doaj.org/toc/2005-6419; https://doaj.org/toc/2005-7563 |
| DOI: | 10.4097/kja.24125 |
| Access URL: | https://doaj.org/article/688e96cd771043cdb5009c5210767128 |
| Accession Number: | edsdoj.688e96cd771043cdb5009c5210767128 |
| Database: | Directory of Open Access Journals |
| ISSN: | 20056419 20057563 52107671 |
|---|---|
| DOI: | 10.4097/kja.24125 |
| Published in: | Korean Journal of Anesthesiology |
| Language: | English |