Academic Journal
Current status and recent advances in reirradiation of glioblastoma
| Title: | Current status and recent advances in reirradiation of glioblastoma |
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| Authors: | Giuseppe Minniti, Maximilian Niyazi, Filippo Alongi, Piera Navarria, Claus Belka |
| Source: | Radiation Oncology, Vol 16, Iss 1, Pp 1-14 (2021) |
| Publisher Information: | BMC, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Target delineation, Recurrent glioblastoma, Reirradiation, Stereotactic radiosurgery, Hypofractionated radiotherapy, Radionecrosis, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Abstract Despite aggressive management consisting of maximal safe surgical resection followed by external beam radiation therapy (60 Gy/30 fractions) with concomitant and adjuvant temozolomide, approximately 90% of WHO grade IV gliomas (glioblastomas, GBM) will recur locally within 2 years. For patients with recurrent GBM, no standard of care exists. Thanks to the continuous improvement in radiation science and technology, reirradiation has emerged as feasible approach for patients with brain tumors. Using stereotactic radiosurgery (SRS) or stereotactic radiotherapy (SRT), either hypofractionated or conventionally fractionated schedules, several studies have suggested survival benefits following reirradiation of patients with recurrent GBM; however, there are still questions to be answered about the efficacy and toxicity associated with a second course of radiation. We provide a clinical overview on current status and recent advances in reirradiation of GBM, addressing relevant clinical questions such as the appropriate patient selection and radiation technique, optimal dose fractionation, reirradiation tolerance of the brain and the risk of radiation necrosis. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1748-717X |
| Relation: | https://doaj.org/toc/1748-717X |
| DOI: | 10.1186/s13014-021-01767-9 |
| Access URL: | https://doaj.org/article/68810263557b47feb022513c26beefd8 |
| Accession Number: | edsdoj.68810263557b47feb022513c26beefd8 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 1748717X |
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| DOI: | 10.1186/s13014-021-01767-9 |
| Published in: | Radiation Oncology |
| Language: | English |