| Title: |
Detection Rate of Prostate Cancer in Repeat Biopsy after an Initial Negative Magnetic Resonance Imaging/Ultrasound-Guided Biopsy |
| Authors: |
Magdalena Görtz, Ann-Kathrin Huber, Tim Linz, Constantin Schwab, Albrecht Stenzinger, Lukas Goertz, David Bonekamp, Heinz-Peter Schlemmer, Markus Hohenfellner |
| Source: |
Diagnostics, Vol 13, Iss 10, p 1761 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
MRI/TRUS fusion biopsy, magnetic resonance imaging, PI-RADS, prostate cancer, prostate-specific antigen, Medicine (General), R5-920 |
| More Details: |
A negative multiparametric magnetic resonance imaging (mpMRI)-guided prostate biopsy in patients with suspected prostate cancer (PC) results in clinical uncertainty, as the biopsy can be false negative. The clinical challenge is to determine the optimal follow-up and to select patients who will benefit from repeat biopsy. In this study, we evaluated the rate of significant PC (sPC, Gleason score ≥7) and PC detection in patients who received a follow-up mpMRI/ultrasound-guided biopsy for persistent PC suspicion after a negative mpMRI/ultrasound-guided biopsy. We identified 58 patients at our institution that underwent repeat targeted biopsy in case of PI-RADS lesions and systematic saturation biopsy between 2014 and 2022. At the initial biopsy, the median age was 59 years, and the median prostate specific antigen level was 6.7 ng/mL. Repeat biopsy after a median of 18 months detected sPC in 3/58 (5%) patients and Gleason score 6 PC in 11/58 (19%). Among 19 patients with a downgraded PI-RADS score at the follow-up mpMRI, none had sPC. In conclusion, men with an initial negative mpMRI/ultrasound-guided biopsy had a high likelihood of not harboring sPC at repeat biopsy (95%). Due to the small size of the study, further research is recommended. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2075-4418 |
| Relation: |
https://www.mdpi.com/2075-4418/13/10/1761; https://doaj.org/toc/2075-4418 |
| DOI: |
10.3390/diagnostics13101761 |
| Access URL: |
https://doaj.org/article/68436df3a3a04aec8ee48169457a0421 |
| Accession Number: |
edsdoj.68436df3a3a04aec8ee48169457a0421 |
| Database: |
Directory of Open Access Journals |
|
Full text is not displayed to guests. |
Login for full access.
|
