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Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications

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Title: Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications
Authors: Khola Ikram, Syed Maaz Hasan, Ch Abdullah, M Zulfiqar, Emad Uddin, Zaib Ali, M. Sajid
Source: Journal of Applied Science and Engineering, Vol 28, Iss 8, Pp 1679-1687 (2025)
Publisher Information: Tamkang University Press, 2025.
Publication Year: 2025
Collection: LCC:Engineering (General). Civil engineering (General)
LCC:Chemical engineering
LCC:Physics
Subject Terms: particle sorting, microfluidics, sla printing, laser cutting, microchannels, Engineering (General). Civil engineering (General), TA1-2040, Chemical engineering, TP155-156, Physics, QC1-999
More Details: The curvature of microchannels significantly influences the direction and amplitude of secondary flow, impacting particle sorting efficiency. Using an inertia-based microchannel model for particle sorting, a detailed flow characterization analysis was done to identify particle sorting and promote standards methods in the microfluidics field. Bends of various angles have numerous uses in microfluidics, and it is essential to comprehend the flow behavior in these microchannels. This work represents the results of a microchannel analysis with various micro-bend angles. Four microchannel designs were studied with outlet angles of 45◦, 60◦, 90◦, and straight channels. Microchannel was fabricated through SLA 3d printing and laser cutting. To investigate the influence of flow-related parameters on systems performance, testing was conducted using 10 & 20 µm, 20 & 60 µm, and 40 & 60 µm sized particles and flow rates of 50-250 µL/min to stimulate red and white blood cells. Furthermore, imaging was done using a microscope, and postprocessing was done through MATLAB Image Processing. This study reveals that a detailed investigation of particle sorting is necessary to produce consistent test techniques for microfluidic devices to enhance medical diagnostic field performance and promote advancement in the biomedical industry.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2708-9967
2708-9975
Relation: http://jase.tku.edu.tw/articles/jase-202508-28-08-0006; https://doaj.org/toc/2708-9967; https://doaj.org/toc/2708-9975
DOI: 10.6180/jase.202508_28(8).0006
Access URL: https://doaj.org/article/683556784e9b4c23b661b76587c963ef
Accession Number: edsdoj.683556784e9b4c23b661b76587c963ef
Database: Directory of Open Access Journals
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  Data: Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications
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  Data: <searchLink fieldCode="AR" term="%22Khola+Ikram%22">Khola Ikram</searchLink><br /><searchLink fieldCode="AR" term="%22Syed+Maaz+Hasan%22">Syed Maaz Hasan</searchLink><br /><searchLink fieldCode="AR" term="%22Ch+Abdullah%22">Ch Abdullah</searchLink><br /><searchLink fieldCode="AR" term="%22M+Zulfiqar%22">M Zulfiqar</searchLink><br /><searchLink fieldCode="AR" term="%22Emad+Uddin%22">Emad Uddin</searchLink><br /><searchLink fieldCode="AR" term="%22Zaib+Ali%22">Zaib Ali</searchLink><br /><searchLink fieldCode="AR" term="%22M%2E+Sajid%22">M. Sajid</searchLink>
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  Data: Journal of Applied Science and Engineering, Vol 28, Iss 8, Pp 1679-1687 (2025)
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  Data: Tamkang University Press, 2025.
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  Data: 2025
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  Data: LCC:Engineering (General). Civil engineering (General)<br />LCC:Chemical engineering<br />LCC:Physics
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  Data: <searchLink fieldCode="DE" term="%22particle+sorting%22">particle sorting</searchLink><br /><searchLink fieldCode="DE" term="%22microfluidics%22">microfluidics</searchLink><br /><searchLink fieldCode="DE" term="%22sla+printing%22">sla printing</searchLink><br /><searchLink fieldCode="DE" term="%22laser+cutting%22">laser cutting</searchLink><br /><searchLink fieldCode="DE" term="%22microchannels%22">microchannels</searchLink><br /><searchLink fieldCode="DE" term="%22Engineering+%28General%29%2E+Civil+engineering+%28General%29%22">Engineering (General). Civil engineering (General)</searchLink><br /><searchLink fieldCode="DE" term="%22TA1-2040%22">TA1-2040</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+engineering%22">Chemical engineering</searchLink><br /><searchLink fieldCode="DE" term="%22TP155-156%22">TP155-156</searchLink><br /><searchLink fieldCode="DE" term="%22Physics%22">Physics</searchLink><br /><searchLink fieldCode="DE" term="%22QC1-999%22">QC1-999</searchLink>
– Name: Abstract
  Label: Description
  Group: Ab
  Data: The curvature of microchannels significantly influences the direction and amplitude of secondary flow, impacting particle sorting efficiency. Using an inertia-based microchannel model for particle sorting, a detailed flow characterization analysis was done to identify particle sorting and promote standards methods in the microfluidics field. Bends of various angles have numerous uses in microfluidics, and it is essential to comprehend the flow behavior in these microchannels. This work represents the results of a microchannel analysis with various micro-bend angles. Four microchannel designs were studied with outlet angles of 45◦, 60◦, 90◦, and straight channels. Microchannel was fabricated through SLA 3d printing and laser cutting. To investigate the influence of flow-related parameters on systems performance, testing was conducted using 10 & 20 µm, 20 & 60 µm, and 40 & 60 µm sized particles and flow rates of 50-250 µL/min to stimulate red and white blood cells. Furthermore, imaging was done using a microscope, and postprocessing was done through MATLAB Image Processing. This study reveals that a detailed investigation of particle sorting is necessary to produce consistent test techniques for microfluidic devices to enhance medical diagnostic field performance and promote advancement in the biomedical industry.
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  Data: 10.6180/jase.202508_28(8).0006
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        Value: 10.6180/jase.202508_28(8).0006
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      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 9
        StartPage: 1679
    Subjects:
      – SubjectFull: particle sorting
        Type: general
      – SubjectFull: microfluidics
        Type: general
      – SubjectFull: sla printing
        Type: general
      – SubjectFull: laser cutting
        Type: general
      – SubjectFull: microchannels
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      – SubjectFull: Engineering (General). Civil engineering (General)
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      – TitleFull: Experimental Investigation of Particle Sorting in Y-Channels with Variable Bifurcation Angles for Microfluidic Applications
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            NameFull: Khola Ikram
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