| Title: |
An allosteric modulator activates BK channels by perturbing coupling between Ca2+ binding and pore opening |
| Authors: |
Guohui Zhang, Xianjin Xu, Zhiguang Jia, Yanyan Geng, Hongwu Liang, Jingyi Shi, Martina Marras, Carlota Abella, Karl L. Magleby, Jonathan R. Silva, Jianhan Chen, Xiaoqin Zou, Jianmin Cui |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Ca2+ activated BK channels are important for neural and muscle function. Here authors use a compound, BC5, to show that the interface between the cytosolic and voltage sensing domains is a major allosteric pathway for Ca2+ binding to open the channel. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-34359-6 |
| Access URL: |
https://doaj.org/article/67b10c912c5146eda08534fccfe9cc8f |
| Accession Number: |
edsdoj.67b10c912c5146eda08534fccfe9cc8f |
| Database: |
Directory of Open Access Journals |
