Bibliographic Details
| Title: |
Research progress on oxidative stress regulatory mechanisms in Streptococcus mutans |
| Authors: |
NING Jia, HU Xin, CHENG Xingqun |
| Source: |
口腔疾病防治, Vol 31, Iss 4, Pp 295-300 (2023) |
| Publisher Information: |
Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
streptococcus mutans, oxidative stress, hydrogen peroxide, oral microecology, dental caries, dental plaque biofilm, cariogenic mechanism, Medicine |
| More Details: |
The oral microecological balance is closely associated with the development of dental caries. Oxidative stress is one of the important factors regulating the composition and structure of the oral microbial community. Streptococcus mutans is closely related to the occurrence and development of dental caries. The ability of S. mutans to withstand oxidative stress affects its survival competitiveness in biofilms. The oxidative stress regulatory mechanisms of S. mutans include the synthesis of reductase, the regulation of iron and manganese uptake by metalloregulatory proteins, transcription regulator Spx, extracellular uptake of glutathione and other related signal transduction systems. The current research focuses on how S. mutans adapts to a complex external environment through an oxidative stress response and its influence on oral microecology. We can design targeted small molecular compounds for key signaling pathways to inhibit oxidative stress and weaken the virulence of S. mutans, which is important for oral microecological modulation and dental caries prevention and treatment. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
Chinese |
| ISSN: |
2096-1456 |
| Relation: |
http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.04.012; https://doaj.org/toc/2096-1456 |
| DOI: |
10.12016/j.issn.2096-1456.2023.04.012 |
| DOI: |
10.12016/j.issn.2096⁃1456.2023.04.012 |
| Access URL: |
https://doaj.org/article/6768b6cae78d4f859748b4f6a8fad41a |
| Accession Number: |
edsdoj.6768b6cae78d4f859748b4f6a8fad41a |
| Database: |
Directory of Open Access Journals |
