| Title: |
The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| Authors: |
Xinglei Liu, Lu Rao, Arne Gennerich |
| Source: |
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| Publisher Information: |
Nature Portfolio, 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimerizing tail of the motor to the AAA + ring. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-020-19477-3 |
| Access URL: |
https://doaj.org/article/66f8acdf26af494eacd6829c2907021d |
| Accession Number: |
edsdoj.66f8acdf26af494eacd6829c2907021d |
| Database: |
Directory of Open Access Journals |
