Bibliographic Details
| Title: |
Physical and functional interaction between A20 and ATG16L1-WD40 domain in the control of intestinal homeostasis |
| Authors: |
Karolina Slowicka, Inmaculada Serramito-Gómez, Emilio Boada-Romero, Arne Martens, Mozes Sze, Ioanna Petta, Hanna K. Vikkula, Riet De Rycke, Eef Parthoens, Saskia Lippens, Savvas N. Savvides, Andy Wullaert, Lars Vereecke, Felipe X. Pimentel-Muiños, Geert van Loo |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Maintaining the intestinal barrier function requires a balance of multiple signalling pathways. Here the authors show that A20, an anti-inflammatory and anti-apoptotic protein, and Atg1611, an autophagy regulator, cross-regulate their respective protein levels and function to serve compensatory and redundant roles in fine-tuning gut barrier homeostasis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-09667-z |
| Access URL: |
https://doaj.org/article/66f4ba80a7fd4950b7b10906aec986dc |
| Accession Number: |
edsdoj.66f4ba80a7fd4950b7b10906aec986dc |
| Database: |
Directory of Open Access Journals |
