A Comparison between single-dose pregabalin and magnesium sulfate in induced hypotension during functional endoscopic sinus surgery: A prospective randomized double-blinded study
| Title: | A Comparison between single-dose pregabalin and magnesium sulfate in induced hypotension during functional endoscopic sinus surgery: A prospective randomized double-blinded study |
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| Authors: | Sarah M. Omar Mousa, Eman Gamal Hassan, Khalid Ahmed Abdo |
| Source: | SVU - International Journal of Medical Sciences, Vol 6, Iss 2, Pp 380-388 (2023) |
| Publisher Information: | South Valley University, Faculty of Medicine, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine |
| Subject Terms: | induced hypotension fess, magnesium sulfate pregabalin single dose, Medicine |
| More Details: | Background: Functional Endoscopic sinus surgery (FESS) is a surgical intervention during which controlled hypotension can improve visibility. Magnesium sulfate is used for controlled hypotension. Pregabalin is also effective in hypotensive anesthesia. Objectives: This study aimed to detect the effect of single preoperative oral pregabalin versus intravenous magnesium sulfate to facilitate induced hypotension during functional endoscopic sinus surgery. Patients and methods: In a randomized, double-blind, prospective study, 60 patients of either sex were divided into 2 equal groups. Group P received an oral pregabalin capsule of 150 mg 30 minutes before general anesthesia. Group M received a single-dose 2 grams of magnesium sulfate 30 minutes before induction of anesthesia. The primary outcome was the total intraoperative consumption of nitroglycerin required to maintain the mean arterial blood pressure (MAP) at the range of 55– 65 mmHg. The secondary outcomes were the quality of the surgical field assessed by the Fromm and Boezaart grading scale, surgeon satisfaction assessed by the five-point Likert scale, and the visual analog pain scores (VAS). Results: The pregabalin group P showed statistically significant lower nitroglycerine doses (1.3±1.2 mg) compared to group M (3.3±1.5 mg) with a P value of |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2735-427X 2636-3402 |
| Relation: | https://svuijm.journals.ekb.eg/article_302441.html; https://doaj.org/toc/2735-427X; https://doaj.org/toc/2636-3402 |
| DOI: | 10.21608/svuijm.2022.180059.1470 |
| Access URL: | https://doaj.org/article/d66e0b48cacf49bb8257f6b889a0b7c5 |
| Accession Number: | edsdoj.66e0b48cacf49bb8257f6b889a0b7c5 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2735427X 26363402 |
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| DOI: | 10.21608/svuijm.2022.180059.1470 |
| Published in: | SVU - International Journal of Medical Sciences |
| Language: | English |