SpotClean adjusts for spot swapping in spatial transcriptomics data

Bibliographic Details
Title: SpotClean adjusts for spot swapping in spatial transcriptomics data
Authors: Zijian Ni, Aman Prasad, Shuyang Chen, Richard B. Halberg, Lisa M. Arkin, Beth A. Drolet, Michael A. Newton, Christina Kendziorski
Source: Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publisher Information: Nature Portfolio, 2022.
Publication Year: 2022
Collection: LCC:Science
Subject Terms: Science
More Details: Spatial transcriptomics experiments profile genome-wide gene expression at localized spots across a tissue. Here, the authors identify spot swapping, an artifact where RNA expressed at one tissue spot binds probes at another, and they propose SpotClean to adjust for it.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-022-30587-y
Access URL: https://doaj.org/article/66cf14fee50f46db8fe773740c41da35
Accession Number: edsdoj.66cf14fee50f46db8fe773740c41da35
Database: Directory of Open Access Journals
More Details
ISSN:20411723
DOI:10.1038/s41467-022-30587-y
Published in:Nature Communications
Language:English