Bibliographic Details
| Title: |
Synthesis, Characterization, and Biological Evaluation of 2-(N-((2′-(2H-tetrazole-5-yl)-[1,1′-biphenyl]-4yl)-methyl)-pentanamido)-3-methyl Butanoic Acid Derivatives |
| Authors: |
Anum Masood, Mohsin Abbas Khan, Irshad Ahmad, Breena, Asim Raza, Farhat Ullah, Syed Adnan Ali Shah |
| Source: |
Molecules, Vol 28, Iss 4, p 1908 (2023) |
| Publisher Information: |
MDPI AG, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
DPPH, FTIR, NMR, antihypertensive activity, antioxidant activity, valsartan, Organic chemistry, QD241-441 |
| More Details: |
This study aimed to evaluate 2-(N-((2′-(2H-tetrazole-5-yl)-[1,1′-biphenyl]-4yl)-methyl)-pentanamido)-3-methyl butanoic acid-based ester derivatives as a new class of angiotensin-II receptor antagonists. For this purpose, a series of compounds were synthesized using a variety of phenols. Their chemical characterization was established by FTIR, 1HNMR, and 13CNMR techniques. The biological activities including antioxidant potentials using the DPPH assay, the antihypertensive assay, the urease enzyme inhibition assay, and the antibacterial assay using agar well diffusion methods were performed. All the new compounds showed significant free radical scavenging potentials more than the parent drug while retaining antihypertensive potentials along with urease inhibition properties. However, the AV2 test compound was found to be the most potent against hypertension. Most of the synthesized analogs showed urease inhibitory actions. Molecular docking studies were performed for all the active analogs to decode the binding detail of the ligands with receptors of the enzyme’s active site. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/28/4/1908; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules28041908 |
| Access URL: |
https://doaj.org/article/669b100bb84a4924af266e40bf8fcf9b |
| Accession Number: |
edsdoj.669b100bb84a4924af266e40bf8fcf9b |
| Database: |
Directory of Open Access Journals |
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