Bibliographic Details
| Title: |
Neuronal hyperexcitability drives central and peripheral nervous system tumor progression in models of neurofibromatosis-1 |
| Authors: |
Corina Anastasaki, Juan Mo, Ji-Kang Chen, Jit Chatterjee, Yuan Pan, Suzanne M. Scheaffer, Olivia Cobb, Michelle Monje, Lu Q. Le, David H. Gutmann |
| Source: |
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022) |
| Publisher Information: |
Nature Portfolio, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Neuronal activity is emerging as a driver of nervous system tumors. Here, the authors show in mouse models of Neurofibromatosis-1 (NF1) that Nf1 mutations differentially drive both central and peripheral nervous system tumor growth in mice through reduced hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-022-30466-6 |
| Access URL: |
https://doaj.org/article/da669970414141a2a3165032a695c25b |
| Accession Number: |
edsdoj.669970414141a2a3165032a695c25b |
| Database: |
Directory of Open Access Journals |
