Bibliographic Details
| Title: |
The 3-Year Effect of the Mediterranean Diet Intervention on Inflammatory Biomarkers Related to Cardiovascular Disease |
| Authors: |
Mireia Urpi-Sarda, Rosa Casas, Emilio Sacanella, Dolores Corella, Cristina Andrés-Lacueva, Rafael Llorach, Gloria Garrabou, Francesc Cardellach, Aleix Sala-Vila, Emilio Ros, Miguel Ruiz-Canela, Montserrat Fitó, Jordi Salas-Salvadó, Ramon Estruch |
| Source: |
Biomedicines, Vol 9, Iss 8, p 862 (2021) |
| Publisher Information: |
MDPI AG, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Biology (General) |
| Subject Terms: |
dietary pattern, nutrition, inflammation, gene expression, cardiovascular diseases, Biology (General), QH301-705.5 |
| More Details: |
The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2227-9059 |
| Relation: |
https://www.mdpi.com/2227-9059/9/8/862; https://doaj.org/toc/2227-9059 |
| DOI: |
10.3390/biomedicines9080862 |
| Access URL: |
https://doaj.org/article/669468ad13eb48c884c31cb83891ba02 |
| Accession Number: |
edsdoj.669468ad13eb48c884c31cb83891ba02 |
| Database: |
Directory of Open Access Journals |
