Academic Journal
Case series of infective endocarditis caused by Granulicatella species
| Title: | Case series of infective endocarditis caused by Granulicatella species |
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| Authors: | Eduardo Leal Adam, Rinaldo Focaccia Siciliano, Danielle Menosi Gualandro, Daniela Calderaro, Victor Sarli Issa, Flavia Rossi, Bruno Caramelli, Alfredo Jose Mansur, Tania Mara Varejao Strabelli |
| Source: | International Journal of Infectious Diseases, Vol 31, Iss C, Pp 56-58 (2015) |
| Publisher Information: | Elsevier, 2015. |
| Publication Year: | 2015 |
| Collection: | LCC:Infectious and parasitic diseases |
| Subject Terms: | Granulicatella spp, Endocarditis, Nutritionally variant streptococci, Infectious and parasitic diseases, RC109-216 |
| More Details: | Background: Nutritionally variant streptococci (NVS) are Gram-positive cocci characterized by their dependence on pyridoxal or cysteine supplementation for growth in standard blood culture media. They are responsible for severe infections in immunocompetent and immunosuppressed hosts, including infective endocarditis (IE). NVS have been divided into two different genera, Granulicatella and Abiotrophia. Methods: We report four cases of IE caused by Granulicatella species, including clinical presentation, echocardiographic characteristics, treatments received, and outcomes. We also performed a literature search for previously reported cases of IE caused by Granulicatella species to better characterize this condition. Results: A total of 29 cases of Granulicatella endocarditis were analyzed, including the four newly reported cases. The aortic (44%) and mitral (38%) valves were those most commonly affected. Multivalvular involvement was observed in 13% of cases. The mean vegetation length was 16 mm. Complications were frequent, including heart failure (30%), embolism (30%), and perivalvular abscess (11%). The most frequent antibiotic regimen (85%) was penicillin or one of its derivatives plus gentamicin. The mortality rate was 17%. Conclusions: Endocarditis due to Granulicatella species is a rare and severe condition. Complications are frequent despite the use of appropriate antibiotic regimens. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1201-9712 1878-3511 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S120197121401683X; https://doaj.org/toc/1201-9712; https://doaj.org/toc/1878-3511 |
| DOI: | 10.1016/j.ijid.2014.10.023 |
| Access URL: | https://doaj.org/article/6636f0db196348058e5adb716d62a313 |
| Accession Number: | edsdoj.6636f0db196348058e5adb716d62a313 |
| Database: | Directory of Open Access Journals |
| ISSN: | 12019712 18783511 |
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| DOI: | 10.1016/j.ijid.2014.10.023 |
| Published in: | International Journal of Infectious Diseases |
| Language: | English |