Bibliographic Details
| Title: |
IL-12 protects from psoriasiform skin inflammation |
| Authors: |
Paulina Kulig, Stephanie Musiol, Sandra Nicole Freiberger, Bettina Schreiner, Gabor Gyülveszi, Giancarlo Russo, Stanislav Pantelyushin, Kenji Kishihara, Francesca Alessandrini, Thomas Kündig, Federica Sallusto, Günther F.L. Hofbauer, Stefan Haak, Burkhard Becher |
| Source: |
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
| Publisher Information: |
Nature Portfolio, 2016. |
| Publication Year: |
2016 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
IL-12 and IL-23 share the common p40 subunit yet have distinct immunological functions with IL-12 typically contributing to Th1 responses and IL-23 to Th17 responses. Here the authors show that current p40 based therapies for psoriasis are counterproductive owing to an IFN-γ-independent tissue protective function of IL-12 in skin. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/ncomms13466 |
| Access URL: |
https://doaj.org/article/65cfea74d59d466a9e896738ae39f149 |
| Accession Number: |
edsdoj.65cfea74d59d466a9e896738ae39f149 |
| Database: |
Directory of Open Access Journals |
