Bibliographic Details
| Title: |
Safety and tolerability study of sotrovimab (VIR-7831) prophylaxis against COVID-19 infection in immunocompromised individuals with impaired SARS-CoV-2 humoral immunity |
| Authors: |
Isabel H. Gonzalez-Bocco, Katherine Beluch, Alyssa Cho, Chloe Lahoud, Fabiola A. Reyes, Dimitrios G. Moshovitis, Gillian M. Unger-Mochrie, Wei Wang, Sarah P. Hammond, Jennifer Manne-Goehler, Sophia Koo |
| Source: |
Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-10 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine (General) |
| Subject Terms: |
COVID-19, Immunocompromised Host, Pre-exposure prophylaxis, Antibodies, Monoclonal, Humanized, Immunity, Medicine (General), R5-920 |
| More Details: |
Abstract Background Multiple vaccines have been approved since August 2021 to prevent infection with SARS-CoV-2; however, 20–40% of immunocompromised people fail to develop SARS-CoV-2 spike antibodies after COVID-19 vaccination and remain at high risk of infection and more severe illness than non-immunocompromised hosts. Sotrovimab (VIR-7831) is a monoclonal neutralizing antibody that binds a conserved epitope on the SARS-CoV-2 spike protein. It is neither renally excreted nor metabolized by P450 enzymes and therefore unlikely to interact with concomitant medications (e.g., immunosuppressive medications). In this open-label feasibility study protocol, we will define the optimal dose and dosing interval of sotrovimab as pre-exposure prophylaxis for immunocompromised individuals as well as its safety and tolerability in this population specifically. Methods We will enroll 93 eligible immunocompromised adults with a negative or low-positive ( |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5784 |
| Relation: |
https://doaj.org/toc/2055-5784 |
| DOI: |
10.1186/s40814-023-01325-y |
| Access URL: |
https://doaj.org/article/ad657617d462466bb5be8c3ad95de933 |
| Accession Number: |
edsdoj.657617d462466bb5be8c3ad95de933 |
| Database: |
Directory of Open Access Journals |
