Effects of L-serine on oxidative stress indices and histopathological changes of pancreas in streptozotocin-induced diabetic mice
| Title: | Effects of L-serine on oxidative stress indices and histopathological changes of pancreas in streptozotocin-induced diabetic mice |
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| Authors: | Mahshad Sheikhi Narani, Akram Vatannejad, Asma Kheirollahi, Farzaneh Ershad Langeroudi, Sara Shokrpoor, Samira Alizadeh, Asie Sadeghi |
| Source: | مجله علمی دانشگاه علوم پزشکی کردستان, Vol 28, Iss 5, Pp 1-12 (2023) |
| Publisher Information: | Kurdistan University of Medical Sciences, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Medicine (General) |
| Subject Terms: | diabetes, l-serine, pancreas, oxidative stress, histopathology, amino acid, Medicine, Medicine (General), R5-920 |
| More Details: | Background and Aim: Diabetes mellitus is a metabolic disorder with an increasing global prevalence that can lead to premature death. High blood glucose is the main lab. abnormality in diabetes mellitus which occurs as a consequence of disorder in pancreatic insulin secretion or function. L -Serine supplementation regarded as safe by the FDA can improve glucose homeostasis and reduce homeostasis model assessment-estimated insulin resistance (HOMA-IR) and oxidative stress. The aim of this study was to investigate the effects of L-serine intake on oxidative stress indices and histopathologic changes in the pancreas of diabetic mice. Materials and Methods: In order to conduct this study, 18 c57bl/6 male mice were purchased and divided into 3 groups (control, diabetic control and diabetic mice treated by L-serine(. Diabetes induced by chemical method (streptozotocin, 200 mg/kg). After four weeks of oral administration of L-Serine (approximately 280 mg/day/mouse), animals were euthanized by guillotine and blood samples and pancreas tissues were obtained to determine biochemical parameters, oxidative stress indices and pathological changes. Results: The results of this study showed that oral administration of the supplement of L-Serine in diabetic mice could help to lower blood sugar levels and could lead to increased catalase enzyme activity (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Persian |
| ISSN: | 1560-652X 2345-4040 |
| Relation: | http://sjku.muk.ac.ir/article-1-7775-en.pdf; https://doaj.org/toc/1560-652X; https://doaj.org/toc/2345-4040 |
| Access URL: | https://doaj.org/article/655d0229d9d846ca9459c47ea72e7c87 |
| Accession Number: | edsdoj.655d0229d9d846ca9459c47ea72e7c87 |
| Database: | Directory of Open Access Journals |
| ISSN: | 1560652X 23454040 |
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| Published in: | مجله علمی دانشگاه علوم پزشکی کردستان |
| Language: | Persian |