Bibliographic Details
| Title: |
A unified model of human hemoglobin switching through single-cell genome editing |
| Authors: |
Yong Shen, Jeffrey M. Verboon, Yuannyu Zhang, Nan Liu, Yoon Jung Kim, Samantha Marglous, Satish K. Nandakumar, Richard A. Voit, Claudia Fiorini, Ayesha Ejaz, Anindita Basak, Stuart H. Orkin, Jian Xu, Vijay G. Sankaran |
| Source: |
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021) |
| Publisher Information: |
Nature Portfolio, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Genetic mechanisms underlying fetal hemoglobin (HbF) regulation and switching are not fully understood. Here, the authors develop a single-cell genome editing functional assay to model how effects of mutation-harbouring functional elements contribute to HbF expression. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-021-25298-9 |
| Access URL: |
https://doaj.org/article/6510aaea4b7a4bf494e21f0d26b79c2e |
| Accession Number: |
edsdoj.6510aaea4b7a4bf494e21f0d26b79c2e |
| Database: |
Directory of Open Access Journals |
