Bibliographic Details
| Title: |
Magnetic resonance elastography resolving all gross anatomical segments of the kidney during controlled hydration |
| Authors: |
Marcos Wolf, Omar Darwish, Radhouene Neji, Michael Eder, Gere Sunder-Plassmann, Gertraud Heinz, Simon Daniel Robinson, Albrecht Ingo Schmid, Ewald V. Moser, Ralph Sinkus, Martin Meyerspeer |
| Source: |
Frontiers in Physiology, Vol 15 (2024) |
| Publisher Information: |
Frontiers Media S.A., 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Physiology |
| Subject Terms: |
MRE, quantitative MRI, QA, kidney imaging, abdominal imaging, physiology, Physiology, QP1-981 |
| More Details: |
Introduction: Magnetic resonance elastography (MRE) is a non-invasive method to quantify biomechanical properties of human tissues. It has potential in diagnosis and monitoring of kidney disease, if established in clinical practice. The interplay of flow and volume changes in renal vessels, tubule, urinary collection system and interstitium is complex, but physiological ranges of in vivo viscoelastic properties during fasting and hydration have never been investigated in all gross anatomical segments simultaneously.Method: Ten healthy volunteers underwent two imaging sessions, one following a 12-hour fasting period and the second after a drinking challenge of >10 mL per kg body weight (60–75 min before the second examination). High-resolution renal MRE was performed using a novel driver with rotating eccentric mass placed at the posterior-lateral wall to couple waves (50 Hz) to the kidney. The biomechanical parameters, shear wave speed (cs in m/s), storage modulus (Gd in kPa), loss modulus (Gl in kPa), phase angle (Υ=2πatanGlGd) and attenuation (α in 1/mm) were derived. Accurate separation of gross anatomical segments was applied in post-processing (whole kidney, cortex, medulla, sinus, vessel).Results: High-quality shear waves coupled into all gross anatomical segments of the kidney (mean shear wave displacement: 163 ± 47 μm, mean contamination of second upper harmonics |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-042X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fphys.2024.1327407/full; https://doaj.org/toc/1664-042X |
| DOI: |
10.3389/fphys.2024.1327407 |
| Access URL: |
https://doaj.org/article/64db9fbdc0ed401890013f0d9c231a70 |
| Accession Number: |
edsdoj.64db9fbdc0ed401890013f0d9c231a70 |
| Database: |
Directory of Open Access Journals |
