| Title: |
Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine |
| Authors: |
Lena Vera Danyeli, Zümrüt Duygu Sen, Lejla Colic, Lisa Kurzweil, Sabrina Gensberger-Reigl, Tamar Macharadze, Florian Götting, Alexander Refisch, Thomas Liebe, Tara Chand, Moritz Kretzschmar, Gerd Wagner, Nils Opel, Fabrice Jollant, Oliver Speck, Matthias H. J. Munk, Meng Li, Martin Walter |
| Source: |
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023) |
| Publisher Information: |
Nature Publishing Group, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: |
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: |
Abstract Ketamine shows rapid antidepressant effects peaking 24 h after administration. The antidepressant effects may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (DMN). A multistage drug effect of ketamine has been suggested, inducing acute effects on dysfunctional network configuration and delayed effects on homeostatic synaptic plasticity. Whether the DMN-centered delayed antidepressant-related changes are associated with the immediate changes remains unknown. Thirty-five healthy male participants (25.1 ± 4.2 years) underwent 7 T magnetic resonance spectroscopy (MRS) and resting-state functional magnetic resonance imaging (rsfMRI) before, during, and 24 h after a single S-ketamine or placebo infusion. Changes in glutamatergic measures and rsFC in the DMN node pregenual anterior cingulate cortex (pgACC) were examined. A delayed rsFC decrease of the pgACC to inferior parietal lobe (family-wise error corrected p (p FWEc) = 0.018) and dorsolateral prefrontal cortex (PFC; p FWEc = 0.002) was detected that was preceded by an immediate rsFC increase of the pgACC to medial PFC (p FWEc |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2158-3188 |
| Relation: |
https://doaj.org/toc/2158-3188 |
| DOI: |
10.1038/s41398-023-02346-0 |
| Access URL: |
https://doaj.org/article/64d55303faf4408db4e8ccf21e4d866a |
| Accession Number: |
edsdoj.64d55303faf4408db4e8ccf21e4d866a |
| Database: |
Directory of Open Access Journals |
