Bibliographic Details
| Title: |
Renal involvement and metabolic alterations in adults patients affected by cystic fibrosis |
| Authors: |
Silvia Lai, Sandro Mazzaferro, Anna Paola Mitterhofer, Enea Bonci, Paolo Giangreco Marotta, Francesco Pelligra, Manuel Murciano, Camilla Celani, Patrizia Troiani, Giuseppe Cimino, Paolo Palange |
| Source: |
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-7 (2019) |
| Publisher Information: |
BMC, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Cystic fibrosis, Chronic kidney disease, Cardiovascular disease, Endothelial dysfunction, Medicine |
| More Details: |
Abstract Background Cystic fibrosis (CF) is one of the most frequent genetic diseases and the median survival of these patients has improved in the last few decades, therefore it becomes necessary to evaluate the long-term complications as renal and cardiovascular risk factors. Aim of the study To evaluate the incidence, the manifestations of renal disease and the possible association with metabolic and endothelial dysfunction markers in the CF population. Materials and methods We performed a cross-sectional, observational study on 226 CF patients. Clinical and laboratory instrumental parameters (metabolic, inflammatory and endothelial dysfunction markers) were evaluated. Results We showed 65 patients with chronic kidney disease (CKD) and 158 patients with a reduced value of forced expiratory volume in 1 s (FEV1), of which 58 patients with a severe reduction of FEV1. Moreover 28 patients had undergone lung transplantation and them had a significant lower estimated Glomerular Filtration Rate (eGFR) with respect to the non-transplanted patients (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1479-5876 |
| Relation: |
http://link.springer.com/article/10.1186/s12967-019-02139-4; https://doaj.org/toc/1479-5876 |
| DOI: |
10.1186/s12967-019-02139-4 |
| Access URL: |
https://doaj.org/article/64cd828bbea646dda79cac089bf3f454 |
| Accession Number: |
edsdoj.64cd828bbea646dda79cac089bf3f454 |
| Database: |
Directory of Open Access Journals |
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