Academic Journal
Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes
| Title: | Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes |
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| Authors: | Kyu Hee Park, Yoon Ji Choi, Won Kee Min, Sun Hwa Lee, Jaeyoung Kim, Sang Hoon Jeong, Ju-Han Lee, Byung Min Choi, Suhyun Kim |
| Source: | Ecotoxicology and Environmental Safety, Vol 263, Iss , Pp 115201- (2023) |
| Publisher Information: | Elsevier, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Environmental pollution LCC:Environmental sciences |
| Subject Terms: | Particulate matter, Heart, Arrhythmia, Heavy metal, Ion channel, Zebrafish, Environmental pollution, TD172-193.5, Environmental sciences, GE1-350 |
| More Details: | Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using a zebrafish embryo model. We found that PM exposure induced cardiotoxicity, such as arrhythmia, during cardiac development. PM exposure caused cardiotoxicity by altering the expression levels of cardiac development (T-box transcription factor 20, natriuretic peptide A, and GATA-binding protein 4)- and ion-channel (scn5lab, kcnq1, kcnh2a/b, and kcnh6a/b)-related genes. In conclusion, this study showed that PM induces the aberrant expression of cardiac development- and ion channel-related genes, leading to arrhythmia-like cardiotoxicity in zebrafish embryos. Our study provides a foundation for further research on the molecular and genetic mechanisms of cardiotoxicity induced by PM exposure. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0147-6513 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0147651323007054; https://doaj.org/toc/0147-6513 |
| DOI: | 10.1016/j.ecoenv.2023.115201 |
| Access URL: | https://doaj.org/article/e642e5e429da4cc0adcaa394c03708ec |
| Accession Number: | edsdoj.642e5e429da4cc0adcaa394c03708ec |
| Database: | Directory of Open Access Journals |
| ISSN: | 01476513 |
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| DOI: | 10.1016/j.ecoenv.2023.115201 |
| Published in: | Ecotoxicology and Environmental Safety |
| Language: | English |