Tumour necrosis factor -308 and -238 promoter polymorphisms are predictors of a null virological response in the treatment of Brazilian hepatitis C patients
| Title: | Tumour necrosis factor -308 and -238 promoter polymorphisms are predictors of a null virological response in the treatment of Brazilian hepatitis C patients |
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| Authors: | Tarciana Grandi, Cláudia Maria Dornelles da Silva, Karine Medeiros Amaral, Paulo Dornelles Picon, Cintia Costi, Nicole Nascimento da Fré, Marilu Fiegenbaum, Tatiana Schäffer Gregianini, Christian Niel, Maria Lucia Rosa Rossetti |
| Source: | Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 3, Pp 345-351 (2014) |
| Publisher Information: | Fundação Oswaldo Cruz (FIOCRUZ), 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Microbiology LCC:Infectious and parasitic diseases |
| Subject Terms: | TNF, polymorphisms, HCV, virological response, Brazil, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216 |
| More Details: | Certain host single nucleotide polymorphisms (SNPs) affect the likelihood of a sustained virological response (SVR) to treatment in subjects infected with hepatitis C virus (HCV). SNPs in the promoters of interleukin (IL)-10 (-1082 A/G, rs1800896), myxovirus resistance protein 1 (-123 C/A, rs17000900 and -88 G/T, rs2071430) and tumour necrosis factor (TNF) (-308 G/A, rs1800629 and -238 G/A, rs361525) genes and the outcome of PEGylated α-interferon plus ribavirin therapy were investigated. This analysis was performed in 114 Brazilian, HCV genotype 1-infected patients who had a SVR and in 85 non-responders and 64 relapsers. A significantly increased risk of having a null virological response was observed in patients carrying at least one A allele at positions -308 [odds ratios (OR) = 2.58, 95% confidence intervals (CI) = 1.44-4.63, p = 0.001] or -238 (OR = 7.33, 95% CI = 3.59-14.93, p < 0.001) in the TNF promoter. The risk of relapsing was also elevated (-308: OR = 2.87, 95% CI = 1.51-5.44, p = 0.001; -238: OR = 4.20, 95% CI = 1.93-9.10, p < 0.001). Multiple logistic regression of TNF diplotypes showed that patients with at least two copies of the A allele had an even higher risk of having a null virological response (OR = 16.43, 95% CI = 5.70-47.34, p < 0.001) or relapsing (OR = 6.71, 95% CI = 2.18-20.66, p = 0.001). No statistically significant association was found between the other SNPs under study and anti-HCV therapy response. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1678-8060 0074-0276 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000300345&lng=en&tlng=en; https://doaj.org/toc/1678-8060 |
| DOI: | 10.1590/0074-0276130372 |
| Access URL: | https://doaj.org/article/64024f1f51414b7f80329e57114a8358 |
| Accession Number: | edsdoj.64024f1f51414b7f80329e57114a8358 |
| Database: | Directory of Open Access Journals |
| ISSN: | 16788060 00740276 |
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| DOI: | 10.1590/0074-0276130372 |
| Published in: | Memorias do Instituto Oswaldo Cruz |
| Language: | English |